Glassy carbon electrode modified with G ‑MoS2‑Nafion acts as an electrochemical biosensor to determine uric acid in human serum.

Glassy carbon electrode modified with G‑MoS2‑Nafion acts as an electrochemical biosensor to determine uric acid in human serum. Mol Med Rep. 2018 Jul 24;: Authors: Yan B, Wang D, Wang Q, Lu X, Du Q, Liang Q, Jiang X, Guo X, Zhou J, Xing Y Abstract At present, the majority of methods used for uric acid (UA) detection are not able to meet the detection requirements with speed, accuracy, high sensitivity, high specificity, a wide linear range or a low cost. Compared with other methods, the electrochemical method has a high sensitivity and fast detection. The present study aimed to identify an electrochemical sensor with high sensitivity, fast detection and a wide linear range for the detection of UA. A glassy carbon electrode modified with graphene‑molybdenum disulfide‑Nafion (G‑MoS2‑Nafion) composites was prepared for use as the working electrode. The morphologies and elemental compositions of the G‑MoS2 composites were characterized by field emission scanning electron microscopy, elemental distribution spectrometry and X‑ray diffraction, respectively. The electrochemical behaviors were investigated by cyclic voltammetry, linear sweep voltammetry and the amperometric i‑t curve (i‑t). The interference of glucose, ascorbic acid and dopamine, and the accuracy and precision of the electrochemical method were subsequently evaluated. The present study identified the following: (1) Only the reduction peak of UA was detect...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research