Decreased SUMOylation of the retinoblastoma protein in keratinocytes during the pathogenesis of vitiligo.

In conclusion, vitiligo lesions in the present study exhibited dysregulated SUMOylation and deSUMOylation balance and dysregulation of cell cycle progression may be present in SUMO1 knockdown HaCaT cells. These results indicate that deSUMOylation of Rb of keratinocytes may serve an important role in vitiligo, providing a novel direction for the study into the mechanism of vitiligo. PMID: 30066925 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30066925?dopt=Abstract

Source: Molecular Medicine Reports - August 3, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research