Comparative hypolipidaemic effects of crude seed powder, aqueous and methanolic seed extracts of Buchholzia coriacea in carbon tetrachloride-induced toxicity in albino rats ( Rattus norvegicus )

AbstractComparative hypolipidaemic effects of aqueous seed extracts, methanolic seed extracts and crude seed powder ofBuchholzia coriacea in rats intoxicated with carbon tetrachloride were evaluated for 56  days. A total of male albino rats (150–200 g) comprising of 12 normal and 132 CCl4-induced toxic rats were divided into 4 major groups: control groups (normal, positive and negative controls) and 3 treatment groups (B. coriacea aqueous extract (BCAE) group,B. coriacea methanolic extract (BCME) group andB. coriacea crude powder (BCCP) group) of 36 albino rats. The major group was split into three sub-groups consisting of three replicates of four rats each. The normal, negative and positive control groups were given 1  ml/kg distilled water, 150 mg/kg of CCl4 and 200  mg/kg of silymarin respectively, while each treatment group was administered 200, 400 and 800 mg/kg respectively. Serum samples were collected from selected rats in each replicate of both treatment and control groups after 7 days of intoxication and at 2 weeks interval for various lipid profile parameters using standard methods. A time-independent significant decrease (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Publication date: Available online 14 November 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Mariceli Comellas, Yamile Marrero, Florence George, Lisa MatthewsAbstractAimTo assess the age and its association with glycemic control (GC) among adults with type 2-diabetes in the United States.Materials and MaterialsData were collected from the National Nutrition Examination Survey (NHANES) 2013 -2014 (n=697), cross-sectional national survey adults with Type2 diabetes. Characteristics included retinopathy diagnosis, blood pressure, albumin-creatinine ratio, hemoglobin A1c (HbA1c), BMI, ch...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionCo-administration of Rg3-KRG+AG is an effective add-on for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes.Graphical abstract
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
Abstract The aim of the present study was to extract and characterize bioactive components from separate body organs of Holothuria leucospilota. Preliminary qualitative assessment of the crude extracts was positive for phenols, terpenoids, carbohydrates, flavonoids, saponins, glycosides, cardiac glycosides, steroids, phlobatannins, and tannins in all body organs evaluated. Phenolics were the most abundant group of bioactives accounting for approximately 80%. The extraction solvent mixtures that yielded most compounds evaluated were methanol/acetone (3:1, v:v) and methanol/distilled water (3:1, v:v). In other analy...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Pathogenic species of mycobacteria are known to use the host cholesterol during lung infection as an alternative source of carbon and energy. Mycobacteria culture in minimal medium (MM) has been used as an in vitro experimental model to study the consumption of exogenous cholesterol. Once in MM, different species of mycobacteria start to consume the cholesterol and initiate transcriptional and metabolic adaptations, upregulating the enzymes of the methylcitrate cycle (MCC) and accumulating a variety of primary metabolites that are known to be important substrates for cell wall biosynthesis. We hypothesize...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
AbstractNo studies evaluating the association between statins and outcomes of patients with seasonal influenza have been performed since the 2007 –2008 and the 2009 pandemic H1N1 influenza seasons. All consecutive hospitalized patients between October 2017 and April 2018, diagnosed with laboratory-confirmed influenza A and B virus, were included. Patients were divided into two groups: statin and non-statin users. Outcomes were 30- and 90-da y mortality, complications (pneumonia, myocarditis, encephalitis, intensive care unit (ICU) transfer, mechanical ventilation, vasopressor support), length of hospital stay, and re...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
A 64-year-old woman with a significant medical history sees her cardiologist for a routine follow-up after a second MI. How do you minimize her risk for future ASCVD events?American College of Cardiology &Medscape
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology Clinical Case Source Type: news
Publication date: Available online 15 November 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Amy Gorman, Khondker R. Hossain, Flemming Cornelius, Ronald J. ClarkeAbstractClusters of positively-charged basic amino acid residues, particularly lysine, are known to promote the interaction of many peripheral membrane proteins with the cytoplasmic surface of the plasma membrane via electrostatic interactions. In this work, cholesterol's effects on the interaction between lysine residues and membranes have been studied. Using poly-l-lysine (PLL) and vesicles as models to mimic the interaction between ly...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
CONCLUSIONS: The Naples prognostic score may be a useful prognostic marker in patients with metastatic colorectal cancer receiving systemic chemotherapy. See Video Abstract at LA PUNTUACIÓN PRONÓSTICA DE NÁPOLES ES UN MARCADOR PRONÓSTICO ÚTIL EN PACIENTES CON CÁNCER COLORRECTAL METASTÁSICO ANTECEDENTES: La inflamación sistémica puede influir en la respuesta a la quimioterapia sistémica o el pronóstico en pacientes con varios tipos de cáncer. La puntuación pronóstica de Nápoles, basada...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
Conclusions: Endoscope-assisted surgery is feasible for lesions involving the perilabyrinthine recesses and increases the likelihood to preserve the structure and function of labyrinth/cochlea, which may provide chances for artificial hearing devices implantation.
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
Publication date: Available online 14 November 2019Source: Journal of Pharmacological SciencesAuthor(s): Mitsuhisa Koga, Yuki Kanaoka, Mana Okamoto, Yuki Nakao, Koshun Inada, Saki Takayama, Yasufumi Kataoka, Atsushi YamauchiAbstractVarenicline is a widely used and effective drug for smoking cessation. We previously reported that varenicline aggravates atherosclerosis in apolipoprotein E knockout (ApoE KO) mice. However, it remains unknown whether varenicline affects cardiovascular events in patients with nicotine addiction. Here, we examined the effect of varenicline on atherosclerotic plaque formation in nicotine-pretreat...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
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