Serum calcium concentration is maintained when bone resorption is suppressed by osteoprotegerin in young growing male rats

Serum calcium is maintained in a narrow range through regulation of Ca metabolism in the intestine, kidney, and bone. Calcium is incorporated and resorbed from bone during bone remodeling via cellular processes as well as by exchange. Both routes contribute to calcium homeostasis. To assess the magnitude of bone turnover contribution to calcium homeostasis we labeled bone with a Ca tracer and measured Ca release following stimulation or suppression of bone resorption. Young growing male rats (n  = 162) were dosed with 45Ca to label skeletal Ca.
Source: Bone - Category: Orthopaedics Authors: Tags: Full Length Article Source Type: research