Molecular Insights into Muscle Homeostasis, Atrophy and Wasting.

Molecular Insights into Muscle Homeostasis, Atrophy and Wasting. Curr Genomics. 2018 Aug;19(5):356-369 Authors: Scicchitano BM, Dobrowolny G, Sica G, Musarò A Abstract Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases. In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention. PMID: 30065611 [PubMed]
Source: Current Genomics - Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research
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