Evolution of Randomized Controlled Trials and Surrogacy of Progression-free Survival in Advanced/metastatic Urothelial Cancer

Clinical trials in advanced/metastatic urothelial cancer have been difficult to perform. We review the current characteristics of randomized controlled trials (RCTs) and evaluate whether PFS could be a potential surrogate endpoint for overall survival (OS) in advanced/metastatic urothelial cancer.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research