Evaluation of PET Brain Radioligands for Imaging Pancreatic {beta}-Cell Mass: Potential Utility of 11C-(+)-PHNO

Conclusion: 11C-(+)-PHNO is a potential marker of BCM, with 2:1 binding of D3 receptors over D2 receptors. Further in vitro and in vivo studies to establish D2/D3 receptor specificity to β-cells is warranted to characterize 11C-(+)-PHNO as a candidate for clinical measurement of BCM in healthy control and diabetic subjects.

Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Bini, J., Naganawa, M., Nabulsi, N., Huang, Y., Ropchan, J., Lim, K., Najafzadeh, S., Herold, K. C., Cline, G. W., Carson, R. E. Tags: Translational Source Type: research