Impact of substance use disorder on gray matter volume in schizophrenia
Comorbid substance use disorders are highly prevalent in individuals with schizophrenia spectrum psychotic disorders and are associated with increased mortality, decreased treatment compliance, and worse outcomes (Ascher-Svanum et al., 2006; Hjorthøj et al., 2015; Moore et al., 2012; Nesvåg et al., 2015; Volkow, 2009). It has been well documented that in schizophrenia there are gray matter deficits in multiple regions including the medial frontal gyrus, temporal cortex, insula, cingulate cortex, thalamus, hippocampus, and amygdala (Ellison-Wright and Bullmore, 2010; Shepherd et al., 2012; Van Erp et al., 2016).
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Margaret Quinn, Maureen McHugo, Kristan Armstrong, Neil Woodward, Jennifer Blackford, Stephan Heckers Source Type: research