Recent developments in cell-SELEX technology for aptamer selection.

CONCLUSIONS: The use of aptamers as therapeutic and diagnostic agents is rapidly evolving, selection techniques such as Cell-SELEX could be beneficial in identifying aptamers when the target is in its native conformation and without prior information of the cognate target, thereby bringing the aptamer development one step closer to the clinic. GENERAL SIGNIFICANCE: The information in this review can serve as a database for the design and development of futuristic oligonucleotide based diagnostics and therapeutics work. PMID: 30059712 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Tags: Biochim Biophys Acta Source Type: research