Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.

In conclusion, in p53wt colon cancer cells chemosensitivity against oxaliplatin or 5-FU could be enhanced by downregulation of CerS5 expression leading to reduced autophagy and mitochondrial respiration. PMID: 30059758 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30059758?dopt=Abstract

Source: Biochimica et Biophysica Acta - July 27, 2018 Category: Biochemistry Authors: Brachtendorf S, Wanger RA, Birod K, Thomas D, Trautmann S, Wegner MS, Fuhrmann DC, Brüne B, Geisslinger G, Grösch S Tags: Biochim Biophys Acta Source Type: research