An update on bone imaging and markers in chronic kidney disease.

An update on bone imaging and markers in chronic kidney disease. Expert Rev Endocrinol Metab. 2016 Nov;11(6):455-466 Authors: Krishnasamy R, Hawley CM, Johnson DW Abstract INTRODUCTION: Bone disorders in chronic kidney disease (CKD) are associated with heightened risks of fractures, vascular calcification, poor quality of life and mortality compared to the general population. However, diagnosis and management of these disorders in CKD are complex and appreciably limited by current diagnostic modalities. Areas covered: Bone histomorphometry remains the gold standard for diagnosis but is not widely utilised and lacks feasibility as a monitoring tool. In practice, non-invasive imaging and biochemical markers are preferred to guide therapeutic decisions. Expert commentary: This review aims to summarize the risk factors for, and spectrum of bone disease in CKD, as well as appraise the clinical utility of dual energy X-ray densitometry, peripheral quantitative computed tomography, high-resolution peripheral quantitative computed tomography, and bone turnover markers. PMID: 30058917 [PubMed]
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

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ConclusionsIn patients with CKD, while the risk factors of major cardiac events differ between in patients with and without diabetes, quantitation with gated MPI could be used effectively in both groups.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Abstract A 56-year-old Philippine seaman without any medical history presented an obstructive and prerenal acute kidney failure near the coasts of Normandy. He was hospitalized in intensive care units because of the seriousness of kidney failure and because of impaired consciousness. Abdominal computed tomography showed a destroyed left kidney, a right hydronephrosis and ureteral strictures, which is typical of urinary tuberculosis. Koch bacillus was positive in urine sample, confirming the diagnosis. Thoracic computed tomography, brain magnetic resonance imaging revealed a tuberculosis miliary with concomitant tu...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
Authors: Heidari B, Al-Hijji MA, Moynagh MR, Takahashi N, Welle G, Eleid M, Singh M, Gulati R, Rihal CS, Lerman A Abstract AIMS: Sarcopenia is a prevalent disease of aging, associated with adverse clinical outcomes. We compared in-hospital adverse outcomes and overall mortality in sarcopenic and non-sarcopenic patients undergoing Transcatheter Aortic Valve Replacement (TAVR). METHODS AND RESULTS: This is a retrospective cohort study including 602 patients who underwent TAVR. Sarcopenia was defined as skeletal muscle mass index
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Authors: Jeon J, Kim S, Yoo H, Kim K, Kim Y, Park S, Jang HR, Kim DK, Huh W, Kim YG, Kim DJ, Oh HY, Lee JE Abstract Background: Contrast-induced nephropathy (CIN) is a major cause of acute kidney injury in chronic kidney disease. Many cancer patients have risk factors for CIN and frequently undergo contrast-enhanced computed tomography (CECT). We aimed to develop a risk prediction model for CIN in cancer patients undergoing CECT. Methods: Between 2009 and 2017, 2,240 cancer patients with estimated glomerular filtration rate (eGFR)
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Publication date: Available online 24 April 2019Source: Gynecologic Oncology ReportsAuthor(s): Brooke Liang, Sara S. Lange, L. Stewart Massad, Rebecca Dick, Kathryn A. Mills, Andrea R. Hagemann, Carolyn K. McCourt, Premal H. Thaker, Katherine C. Fuh, David G. Mutch, Matthew A. Powell, Lindsay M. KurokiAbstractObjectiveTo assess the renal outcomes of gynecologic oncology patients who present with hydronephrosis and acute kidney injury (AKI), have
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
CONCLUSIONS: IL-6 and CS were significantly associated with 5-year risk of all-cause mortality in CKD patients. Our study suggests an involvement of chronic inflammation linked to coronary artery calcification that is likely to contribute to the cardiovascular mortality in patients with impaired renal function. PMID: 30991230 [PubMed - as supplied by publisher]
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Abstract Positron emission tomography combined with computed tomography (PET/CT) is a nuclear imaging technique which provides anatomical and functional information. PET/CT is increasingly used in non-oncological nephrology since conventional radiological approaches after injection of contrast agents are relatively contra-indicated in patients with chronic kidney disease (CKD). PET/CT after i.v. injection of 18F-fluoro-deoxy-glucose (FDG) is not toxic and is characterized by a high sensitivity. The level of irradiation (∼5mSv) is acceptable. CKD does not significantly influence tissue uptake of 18F-FDG. The pu...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
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Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
ConclusionKSS should be offered in low-risk UTUC when feasible, whereas RNU is the treatment of choice in organ-confined high-risk UTUC. Intravesical recurrence (IVR) is common after RNU, but a single postoperative dose of mitomycin instillation decreases IVR. Endourological management has high local and bladder recurrence rates; however, its effect on CSS or overall survival OS is unclear. RNU is associated with significant risk of chronic kidney disease. Careful selection of patients and risk stratification are mandatory, and patients should be followed according to strict protocols.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Patients with chronic kidney disease (CKD) have an increased risk of adverse cardiovascular/cerebrovascular events. The aim of this study is to clarify whether stress myocardial perfusion single-photon emission computed tomography (SPECT) could predict cardiovascular/cerebrovascular events. In the Gunma-CKD SPECT Study, a multicenter prospective cohort trial, 311 patients with CKD (estimated glomerular filtration rate #x3c; 60 min/mL/1.73 m2) including 50 patients on hemodialysis underwent stress99mTc-tetrofosmin SPECT for suspected ischemic heart disease and were followed for 2 years. The primary endpoint was the occurren...
Source: Cardiology - Category: Cardiology Source Type: research
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