An update on bone imaging and markers in chronic kidney disease.

An update on bone imaging and markers in chronic kidney disease. Expert Rev Endocrinol Metab. 2016 Nov;11(6):455-466 Authors: Krishnasamy R, Hawley CM, Johnson DW Abstract INTRODUCTION: Bone disorders in chronic kidney disease (CKD) are associated with heightened risks of fractures, vascular calcification, poor quality of life and mortality compared to the general population. However, diagnosis and management of these disorders in CKD are complex and appreciably limited by current diagnostic modalities. Areas covered: Bone histomorphometry remains the gold standard for diagnosis but is not widely utilised and lacks feasibility as a monitoring tool. In practice, non-invasive imaging and biochemical markers are preferred to guide therapeutic decisions. Expert commentary: This review aims to summarize the risk factors for, and spectrum of bone disease in CKD, as well as appraise the clinical utility of dual energy X-ray densitometry, peripheral quantitative computed tomography, high-resolution peripheral quantitative computed tomography, and bone turnover markers. PMID: 30058917 [PubMed]
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

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ConclusionsMönckeberg medial calcinosis is an incidental finding on panoramic or CBCT imaging. Clinically and radiographically, its importance for the clinician is its strong association with diabetes and chronic kidney disease. The significance of Mönckeberg sclerosis of the infraorbital arteries is unknown. Radiologists and clinicians should be aware of this entity and the importance of documentation of any findings.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
CONCLUSIONS: Our proteomics approach identified plasma KIM-1 as a risk marker for cardiovascular mortality and coronary artery calcification in three independent ESRD-cohorts. The improved risk prediction for cardiovascular mortality by plasma proteomics merit further studies. PMID: 30499038 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
CONCLUSIONSDespite no measurable disease remaining on preinfusion imaging, CAR-T cell expansion was observed in 7 of 8 pts in this setting, similar to the expansion in adults with active r/r DLBCL. Five of the 8 pts remained on study and were progression free> 12 months after infusion, which is higher than would be estimated with bridging chemotherapy alone. These data provide preliminary evidence that CAR-T cells provide clinical benefit in pts with r/r DLBCL who achieve CR with subsequent therapies and for design of CAR-T cell trials as consolidative therapy.DisclosuresBishop: United Healthcare: Employment; Seattle Ge...
Source: Blood - Category: Hematology Authors: Tags: 626. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Prospective Clinical Trials: Poster II Source Type: research
Introduction: CMML is a myeloid neoplasm hallmarked by cytopenias and a peripheral monocytosis. Although uniformly fatal, many patients (pts) are diagnosed incidentally and are monitored without treatment. Therapy is implemented when symptomatic cytopenias, splenomegaly, or bone marrow progression occur. Higher white blood cell count (WBC) and absolute monocyte count (AMC) are associated with inferior OS, however, they are currently not an indication for treatment. Case reports have demonstrated a putative link between CMML monocytes and end organ damage (EOD), which has not been systematically explored. We hypothesize tha...
Source: Blood - Category: Hematology Authors: Tags: 637. Myelodysplastic Syndromes-Clinical Studies: Poster II Source Type: research
Siemens (NYSE:SI) Healthineers said today that it won FDA clearance for its Cios Spin mobile C-arm device for intraoperative 3D imaging. The newly cleared Cios Spin produces 3D computed tomography-like imaging for orthopedic, trauma and spinal surgery that Siemens claims can reduce the rate of revisions and need for post-operative CT. The Cios Spin supports both 2D and 3D imaging and can be used for a variety of procedures, including vascular imaging, Siemens said. The system also features NaviLink 3D digital navigation and flat panel detector technology and other software packages. “Siemens Healthineers is...
Source: Mass Device - Category: Medical Devices Authors: Tags: 510(k) Food & Drug Administration (FDA) Imaging Regulatory/Compliance Siemens Healthineers Source Type: news
Conclusion: The administration of both IV and intra-arterial contrast is associated with a risk of AKI. Multifactorial AKI was associated with worse outcomes, while CIN was associated with better outcomes.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
Publication date: Available online 5 October 2018Source: Journal of Vascular and Interventional RadiologyAuthor(s): Wenhui Zhou, Sanna E. Herwald, Raul N. Uppot, Ronald S. ArellanoAbstractPurposeTo assess safety and renal-function outcomes after microwave (MW) ablation of localized stage T1 renal cell carcinoma (RCC).Materials and MethodsA retrospective review was conducted of 38 patients (28 men; mean age, 69 y; range, 51–88 y) who underwent computed tomography (CT)–guided MW ablation for stage T1N0M0 RCC. Baseline and follow-up renal function surrogates including creatinine level and estimated glomerular filt...
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Authors: Higuchi R, Tobaru T, Hagiya K, Saji M, Takamisawa I, Shimizu J, Iguchi N, Takanashi S, Takayama M Abstract The therapeutic role of transcatheter aortic valve implantation (TAVI) in high surgical risk or inoperable cases has been established. Most of the candidates for TAVI are elderly and have multiple comorbidities including chronic kidney disease. However, contrast-enhanced computed tomography and coronary angiography, both of which require iodine contrast media, are essential for pre-procedural planning. In addition, TAVI could have adverse effects on kidney function including contrast media-induced nep...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Conclusion Gold nanoparticles conjugated to an anti-collagen-I antibody are able to visualize kidney fibrosis in vitro and in situ and may be useful for nondestructive quantification of tissue fibrosis.
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
AbstractRenal osteodystrophy (ROD) is a metabolic skeletal pathology that frequently affects the orofacial region and presents with characteristic radiological manifestations. This paper reports a case of ROD causing diffused orofacial bone alterations in a female patient with end-stage chronic kidney disease. The radiological features on panoramic, posteroanterior and lateral skull and computed tomography radiographs are described for this case. Previous reports in the literature are reviewed and discussed with a focus on radiological characteristics and differential diagnoses.
Source: Oral Radiology - Category: Radiology Source Type: research
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