Aquagenic wrinkling of the palms in association with cystic fibrosis manifesting after a lung transplantation

A 28-year-old woman with cystic fibrosis presented with painful wrinkling of the palms shortly after immersion in water. She had undergone a bilateral single sequential lung transplant five months before. Pertinently, before this, she had been asymptomatic. Her signs and symptoms were consistent with aquagenic wrinking of the palms. Her immunosuppressive regime included tacrolimus 4.5 mg BD, mycophenolate mofetil 500 mg BD, and prednisolone 10 mg OD. Aquagenic wrinking of the palms is a rare condition in which white papules and plaques and excessive wrinkling of the palmar skin occur within minutes of water exposure.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research