Chronic graft-versus-host disease presenting as generalized scleroderma: A rare entity

Introduction: Graft-versus-host disease (cGVHD) is a major complication of allogeneic stem cell transplantation which develops due to the action of immunocompetent donor lymphocytes against immunosupressed recipient host cells. Onset of the disease after 100 days of transplantation is termed as chronic GVHD. Lichenoid and sclerodermoid changes are the two main cutaneous presentations of chronic GVHD. Sclerodermoid GVHD was first described by Master et al. in 1975 and is considered a severe form of the disease eventually making the patient disabled.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research