Concordant and discordant cancers in familial atypical multiple mole melanoma syndrome (FAMMM) with the CDKN2A mutation

Background: The FAMMM syndrome with the CDKN2A mutation is a major hereditary cause of malignant melanoma. In addition to melanoma, there is a high incidence of pancreatic cancer, breast cancer, and lung cancer in CDKN2A families. We were interested in determining the incidence of other malignancies not known to be associated (discordant) with FAMMM syndrome.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research