Copeptin Testing Tops Water-Deprivation for Diabetes Insipidus Dx (CME/CE)

(MedPage Today) -- But adverse effects were more common with plasma-based diagnostic
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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ConclusionsGradient washout has not been widely reported in humans, although it has been observed in the mammalian kidneys after prolonged polyuria. Although not a problem with aquaporin protein expression or production, gradient washout causes a different type of secondary nephrogenic diabetes insipidus because the absence of a medullary gradient impairs water reabsorption. We report a case of an infant who developed complex water and sodium imbalances after brain injury. Prolonged polyuria resulting from both water and solute diuresis with low enteral protein intake was thought to cause a urea gradient washout and second...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusion. CP diagnosed in the elderly shows a similar distribut ion by sex and histologic forms than that diagnosed at younger ages. At presentation visual field alterations and headaches are the main clinical symptoms which improve substantially with surgery. However, surgery, mainly NTR, is accompanied by worsening of pituitary function, especially DI, which s eems to be a predictor of mortality in this population.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research
We are supporting theThe Pituitary Foundation’s campaign to change the name of diabetes insipidus to‘pituitary insipidus - desmopressin dependent’ (PIDD).The term‘diabetes insipidus’ is very often mistaken for diabetes mellitus by health care professionals (HCPs) and the general public. Although both conditions share the term‘diabetes’, they are completely unrelated and mean very different things.The challenge for diabetes insipidus patients is when they need hospital attention (A&E, surgery, or on a hospital ward). Many HCPs are unaware of DI and assume the patient has di...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Authors: Al Dahmani K, Afandi B, Elhouni A, Dinwal D, Philip J, Bashier A, Beshyah SA, Nagelkerke N, Alkaabi JM Abstract Objectives: We sought to ascertain the clinical characteristics and control rate of acromegaly in the UAE. Methods: We conducted a multicenter retrospective analysis of all patients presenting with acromegaly to six endocrine centers in the UAE between November 2010 and December 2018. Demographic, clinical, biochemical, and radiologic data were collected. Patients were considered controlled if normal insulin-like growth factor-1 (IGF-1) level and growth hormone
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Rationale: Xanthogranuloma of the sellar region is exceedingly rare, and described in only a handful of case reports. Herein, we present a case of xanthogranuloma of the sellar region to improve our knowledge for the diagnosis and management of this unusual disease. Patient concerns: A 50-year-old female presented with the symptoms of intermittent vomiting, occasional head discomfort, and diabetes insipidus of 1 month duration. Diagnoses: Magnetic resonance imaging showed a large well-defined, vase-like, heterogeneous mass in the sellar region. The lesion showed mixed signal with hierarchical signal presentation. F...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
AbstractBackground/ObjectiveDysnatremia is common in severe traumatic brain injury (TBI) patients and may contribute to mortality. However, serum sodium variability has not been studied in TBI patients. We hypothesized that such variability would be independently associated with mortality.MethodsWe collected 6-hourly serum sodium levels for the first 7  days of ICU admission from 240 severe TBI patients in 14 neurotrauma ICUs in Europe and Australia. We evaluated the association between daily serum sodium standard deviation (dNaSD), an index of variability, and 28-day mortality.ResultsPatients were 46  ±...
Source: Neurocritical Care - Category: Neurology Source Type: research
Abstract OBJECTIVE: Life expectancy has increased over the past century, causing a shift in the demographic distribution toward older age groups. Elderly patients comprise up to 14% of all patients with pituitary tumors, with most lesions being nonfunctioning pituitary adenomas (NFPAs). Here, the authors evaluated demographics, outcomes, and postoperative complications between nonelderly adult and elderly NFPA patients. METHODS: A retrospective review of 908 patients undergoing transsphenoidal surgery (TSS) for NFPA at a single institution from 2007 to 2019 was conducted. Clinical and surgical outcomes and po...
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
Conclusion: Copeptin levels in this infant are consistent with levels described in adults and older children. Obtaining copeptin levels may improve providers ’ ability to quickly diagnose and manage SIADH amongst other heterogeneous causes of hyponatremia. Lastly, trending copeptin levels improved providers’ ability to monitor SIADH progression, and may allow preemptive fluid titration for children with bi- or tri-phasic shifts in osmoregulation afte r neurological procedures.Horm Res Paediatr
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
ConclusionsTo improve reliability and comparability we propose the following definition for postoperative DI: polyuria (urine production  >  300 ml/hour for 3 h) accompanied by a urine specific gravity (USG)   300 mosmol/kg, or serum sodium >  145 mmol/L. To prevent unnecessary treatment with desmopressin, we present an algorithm for the diagnosis and treatment of postoperative DI.
Source: Pituitary - Category: Endocrinology Source Type: research
Discussion Syphilis is caused by the spirochete Treponema pallidum. It is a very old disease that despite understanding the organism and readily available treatment, still causes disease. Syphilis is transmitted sexually. According to the Centers for Disease Control, “[i]n 2018, a total of 35,063 cases of [Primary and Secondary] syphilis were reported in the United States, yielding a rate of 10.8 cases per 100,000 population …. This rate represents a 14.9% increase compared with 2017 (9.4 cases per 100,000 population), and a 71.4% increase compared with 2014 (6.3 cases per 100,000 population).” The incre...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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