Ideal cardiovascular health is inversely associated with non-alcoholic fatty liver disease: a prospective analysis

Non-alcoholic fatty liver disease (NAFLD) is one of the most important causes of liver diseases worldwide with a global prevalence currently estimated to be 24% and will probably emerge as the leading cause of end-stage liver disease in the coming decades.1-3 In addition to progression into nonalcoholic steatohepatitis (NASH), cirrhosis, and liver carcinoma,4 NAFLD has also been proved to be independently associated with cardiovascular disease, chronic kidney disease, type 2 diabetes, neoplasms, and other extrahepatic diseases.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Research Study Source Type: research

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Study Objectives:Obstructive sleep apnea (OSA) is associated with nonalcoholic fatty liver disease (NAFLD) and related advanced fibrosis. We studied the treatment of OSA with continuous positive airway pressure (CPAP) in a population with NAFLD.Methods:Using an institutional database (2010–2014), we identified patients with NAFLD and OSA and studied changes in serum aminotransferases before and after CPAP use. We defined suspected NAFLD (sNAFLD) as serum alanine aminotransferase (ALT)> 30 U/L for men and> 19 U/L for women in the absence of known causes of chronic liver disease. The aspartate aminotransferase (A...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Conclusions:In a middle-aged population-based cohort, the prevalence of a RERA index≥ 5 events/h was low (3.8%) and was not associated with negative clinical outcomes when using the currently recommended scoring criteria of the American Academy of Sleep Medicine.Citation:Ogna A, Tobback N, Andries D, Preisig M, Vollenweider P, Waeber G, Marques-Vidal P, Rubio JH, Heinzer R. Prevalence and clinical significance of respiratory effort-related arousals in the general population.J Clin Sleep Med. 2018;14(8):1339–1345.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
We describe an 8-year-old male with a pathogenicUNC80 mutation, intellectual disability, hypotonia and epilepsy with severe central sleep apnea (213.5 events/h) on polysomnography (PSG). We also describe a 20-month-old female with aKCNJ11 mutation, neonatal diabetes and developmental delay who had severe central sleep apnea (131.1 events/h). Both patients had irregular respiratory patterns during sleep and wakefulness and were placed on empiric bilevel positive airway pressure therapy, which was well tolerated with resolution of abnormal respiratory control and hypercapnia. Patients withUNC80 andKCNJ11 gene mutations may h...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
In conclusion, we have demonstrated AE has benefits to regulate DPP-4 and GLP-1R, to reduce oxidative stress and renal fibrosis, with resultant to improve renal function and prevent diabetic renal damage. Taken together, F2 could be more promising to be developed as adjuvant for diabetic nephropathy.Graphical abstract
Source: Journal of Food and Drug Analysis - Category: Food Science Source Type: research
Capillary Biomedical Inc. has raised $2.9 million in a seed funding that will help it bring its diabetes management technology to market. The round was led by the Cove Fund with participation by a syndicate of Angel Groups and accredited investors. Irvine, California-based Capillary Biomedical said it plans to use the funds for clinical studies to support regulatory clearance and preparation for commercial launch in 2019. CapBio i s developing a novel infusion set for use with insulin pumps for…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 14 August 2018Source: Life SciencesAuthor(s): Leônidas Graças Mendes-Junior, Leandro Ceotto Freitas-Lima, Janaína Ribeiro Oliveira, Marcos B. Melo, Carlos Eduardo Mendes D'Angelis, Jonh David Feltenberger, Igor Viana Brandi, Bruna Mara Aparecida Carvalho, André Luiz Sena Guimarães, Alfredo Maurício Batista De Paula, Carlos Eduardo Mendes D'Angelis, Maria José Campagnole-Santos, Robson Augusto Souza Santos, Valdir Andrade Braga, Sérgio Henrique Sousa SantosAbstractDiabetic cardiomyopathy (DC) describes diabetes-associated changes in th...
Source: Life Sciences - Category: Biology Source Type: research
Abstract Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given ...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Endocrinol Metab Clin North Am Source Type: research
Publication date: 1 December 2018Source: Sensors and Actuators B: Chemical, Volume 275Author(s): Xiaoxue Ye, Mingshi Li, Ye Hu, Zhengguo Wang, Yanying Wang, Hongping Deng, Xiaoxing Xiong, Chunya Li, Dong SunAbstractA photoelectrochemical immunosensor was fabricated for squamous cell carcinoma antigen (SCCA) assay with high performances by using MoSe2 nanosheets and hollow gold nanospheres as photosensitive materials. MoSe2 nanosheets were simply synthesized with a hydrothermal method using 1,3-di-(3-thioacetylpropyl)-imidazolium bromide (DITAPIBr) ionic liquid as a morphological controlling reagent, selenium powder, and so...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
There is mounting evidence that besides increasing risk of cirrhosis, end stage liver disease and hepatocellular carcinoma, non alcoholic fatty liver disease (NAFLD) also affects risk of disease in organs beyond the liver[1]. For example, NAFLD is an independent risk factor for cardiovascular disease[2], type 2 diabetes[3] and chronic kidney disease[4], and NAFLD also increases risk of cardiac arrhythmias and aortic valve disease [1]. However, whether NAFLD is a risk factor for impaired myocardial function is uncertain.In a study of 308 asymptomatic subjects recruited from attendees at a Health Promotion Centre in a Univer...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of MetS. However, accumulating evidence indicates that the effe...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
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