Secondary Acute Lymphoblastic Leukemia, a retrospective analysis from Washington University and meta-analysis of published data

Secondary malignancies are broadly defined as a group of cancers arising after a previous malignancy and have become increasingly appreciated due to improvement in cancer survival. Therapy-related malignancies are a sub-group of secondary malignancies in which the exposure to prior chemotherapy or radiation therapy is instrumental to the establishment of the secondary cancer. Other than the role of previous therapies, underlying genetic predisposition, immunodeficiency states or simple coincidence have all also been invoked as potential causative factors for the development of secondary cancers [1].

Source: Leukemia Research - August 1, 2018 Category: Hematology Authors: Francesca Ferraro, Feng Gao, Keith Stockerl-Goldstein, Peter Westervelt, John F. DiPersio, Armin Ghobadi Source Type: research