Philadelphia-Like Acute Lymphoblastic Leukemia: Diagnostic dilemma and management perspectives

Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy treated with intensive chemotherapy[1]. In children ALL therapy was a success story [2], however in adults outcomes remain poor [3]. The poor prognosis of adult-ALL is attributed to the accumulation of poor prognostic features including, but not limited to, the higher frequency of poor-risk genomic subgroups, the lower tolerability to prolonged courses of intensive chemotherapy and the high therapy related mortality after hematopoietic cell transplantation (HCT) [4].

Source: Experimental Hematology - August 1, 2018 Category: Hematology Authors: Ahmed Kotb, Riad El Fakih, Amr Hanbali, Yousef Hawsawi, Feras Alfraih, Shahrukh Hashmi, Mahmoud Aljurf Tags: Review Source Type: research