Intracellular Lipids are an Independent Cause of Liver Injury and Chronic Kidney Disease in Non Alcoholic Fatty Liver Disease-like Context

ConclusionsThis study highlights the crucial role that lipids play in the independent development of both NAFLD and CKD and demonstrates the importance of lipid-lowering treatments in various metabolic diseases featured by lipid load, from the “rare” GSDIa to the “epidemic” morbid obesity or type 2 diabetes.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research

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Melissa J. Conroy, Stephen G. Maher, Ashanty M. Melo, Suzanne L. Doyle, Emma Foley, John V. Reynolds, Aideen Long, Joanne Lysaght
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
DIABETES type 2 patients should exercise to lower their risk of high blood sugar symptoms. But, this is the one thing all diabetics must do after walking, or risk painful foot complications.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
What is the public health burden of eating disorders? The burden is a product of two factors: 1) the prevalence of these disorders and 2) the degree of disability (including morbidity and mortality) caused by these disorders. In this issue of Biological Psychiatry, Udo and Grilo (1) offer new numbers for this “burden equation.” Using data from the 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-III), they have attempted to estimate the prevalence and correlates, including self-reported disability, of anorexia nervosa, bulimia, and binge-eating disorder.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Solipsistic novels, a study of narcissism, a biography of a Michelin starred chef ... here are some of the best, from Dostoevsky to Karl Ove KnausgaardA level of self-absorption is a necessity for most writers. Every novel is ultimately about its author, and I like my non-fiction self-obsessed, too. Then there are the works that combine the two.Norwegian authorKarl Ove Knausgaard specialises in semi-fictional self-obsession.A Death in the Family, translated by Don Bartlett, charts a period of his life centring around his alcoholic father ’s death. Knausgaard has a spectacular gift for finding profundity in the mundan...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Books Culture Karl Ove Knausgaard Fyodor Dostoevsky Psychology Society Biography books Fiction Source Type: news
Are the recent FDA label changes regarding the cardiovascular risks of testosterone therapy supported by available evidence?Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Abstract Obesity, together with insulin resistance, promotes multiple metabolic abnormalities and is strongly associated with an increased risk of chronic disease including type 2 diabetes (T2D), hypertension, cardiovascular disease, non-alcoholic fatty liver disease and chronic kidney disease (CKD). The incidence of obesity continues to rise in astronomical proportions throughout the world and affects all different stages of the lifespan. Importantly, the proportion of women of reproductive age who are overweight or obese is increasing at an alarming rate and has potential ramifications for offspring health and d...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
AbstractBackgroundWorldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as non-alcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat).MaterialsWe included 60 male rat...
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research
Abstract Lipoprotein (a) [Lp(a)] is an independent but moderate, predictor for coronary heart disease (CHD) prevalence and severity. Several established and emerging cardiovascular (CV) risk factors including age, gender, ethnicity, smoking, dyslipidemia, hypertension, obesity, type 2 diabetes mellitus, alcohol consumption, arterial stiffness and hyperuricemia have been linked to Lp(a) metabolism. Apart from CHD, Lp(a) has been also associated with non-cardiac vascular diseases and diseases associated with increased CV risk such as chronic kidney disease, metabolic syndrome, non-alcoholic fatty liver disease, erec...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
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Source: Journal of Advanced Research - Category: Research Source Type: research
Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of MetS. However, accumulating evidence indicates that the effe...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
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