Impact of Practice Facilitation in Primary Care on Chronic Disease Care Processes and Outcomes: a Systematic Review
The objective is to evaluate the impact of practice facilitation on chronic disease outcomes in the primary care setting.MethodsThis systematic review examined North American studies from PubMed, EMBASE, and Web of Science (database inception to August 2017). Investigators independently extracted and assessed the quality of the data on chronic disease process and clinical outcome measures. Studies implemented practice facilitation and reported quantifiable care processes and patient outcomes for chronic disease. Each study and their evidence were assessed for risk of bias and quality according to the Cochrane Collaboration and the Grade Collaboration tool.ResultsThis systematic review included 25 studies: 12 randomized control trials and 13 prospective cohort studies. Across all studies, practices and their clinicians were aware of the implementation of practice facilitation. Improvements were observed in most studies for chronic diseases including asthma, cancer (breast, cervical, and colorectal), cardiovascular disease (cerebrovascular disease, coronary artery disease, dyslipidemia, hypertension, myocardial infarction, and peripheral vascular disease), and type 2 diabetes. Mixed results were observed for chronic kidney disease and chronic illness care.DiscussionOverall, the results suggest that practice facilitation may improve chronic disease care measures. Across all studies, practices were aware of practice facilitation. These findings lend support for the potential expa...
Antonio Macci ò, Silvia Busquets, Clelia Madeddu, Josep M. Argilés
Nikitas N. Nomikos, Pantelis T. Nikolaidis, Caio V. Sousa, Apostolos E. Papalois, Thomas Rosemann, Beat Knechtle
CONCLUSIONS: Patients with STEMI or HF can safely tolerate intra-arterial CCB during radial catheterization. PMID: 30555053 [PubMed - as supplied by publisher]
Publication date: Available online 17 December 2018Source: Redox BiologyAuthor(s): Jayshree Hirpara, Jie Qing Eu, Joanna Kia Min Tan, Andrea L. Wong, Marie-Veronique Clement, Kong Li Ren, Naoto Ohi, Takeshi Tsunoda, Jianhua Qu, Boon Cher Goh, Shazib PervaizAbstractThe ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime. Here we report evidence of enhanced reliance on mitochondrial oxidative phosphorylation (OXPHOS) in oncogene-ad...
Dalton Trans., 2019, Advance Article DOI: 10.1039/C8DT03266A, PaperLeila Tabrizi, Lukman O. Olasunkanmi, Olatomide A. Fadare The cyclometalated ruthenium(II) complex was synthesized and studied for cytotoxicity. The interaction of Ru(II) complex with COX-2 was studied by experimental and molecular docking. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019,55,63-66 DOI: 10.1039/C8CC08866G, CommunicationYan Li, Longjie Li, Xunbo Lu, Yulong Bai, Yufan Wang, Yuzhou Wu, Fangrui Zhong Inspired by the heme iron-catalyzed radical insertion of dioxygen to the tryptophan indole ring, herein we utilize alkylperoxy radical species as a coupling partner to trigger a peroxycyclization of readily accessible tryptophan derivatives and enable the first synthesis of peroxypyrroloindolenines. The content of this RSS Feed (c) The Royal Society of Chemistry
Analyst, 2019, Advance Article DOI: 10.1039/C8AN02092B, PaperAritri Ghosh, Sreyan Raha, Susmita Dey, Kabita Chatterjee, Amit Roy Chowdhury, Ananya Barui FTIR spectroscopy and Raman spectroscopy of biological analytes are increasingly explored as screening tools for early detection of cancer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
India's federal drug regulator said on Tuesday a Reuters report that Johnson&Johnson knew for decades that cancer-causing asbestos lurked in its baby powder was "under consideration".
Abstract Free radicals are closely related to the occurrence and development of aging, cancer and inflammation. In this paper, the microbial transglutaminase (MTGase) was used as a catalyst to graft the collagen peptide (COP) molecules on the amino group of carboxymethyl chitosan sulfate (CMCS) to improve the antioxidant effects. FT-IR and NMR spectroscopy were used to confirm the successful grafting of COP to CMCS. Degree of substitution (DS) of CMCS-COP could be controlled by adjusting the reaction conditions. With the increase of concentration, the ability of each sample on scavenging capacity and reducibility ...
Publication date: Available online 17 December 2018Source: Meta GeneAuthor(s): Andrea Mary Francis, R. Ramya, Nalini Ganesan, P. Kumarasamy, Solomon F.D. Paul, A.K. Munirajan, M. DivyaAbstractThe most common cancer in women is breast cancer, and it poses serious health issues in women, leading to increased mortality rates. Estrogen and its metabolites have been established as risk factors for breast cancer. Determining the role of genetic variants having functional involvement in regulating the estrogen concentration and detoxifying the toxic estrogen metabolites through estrogen hydroxylation by CYP1A1, CYP1B1, and catech...
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