Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population

Conclusions The most significant association with childhood SSNS was detected in the HLA-DR/DQ region. Further HLA allele/haplotype analyses should enhance our understanding of molecular mechanisms underlying SSNS.

Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Jia, X., Horinouchi, T., Hitomi, Y., Shono, A., Khor, S.-S., Omae, Y., Kojima, K., Kawai, Y., Nagasaki, M., Kaku, Y., Okamoto, T., Ohwada, Y., Ohta, K., Okuda, Y., Fujimaru, R., Hatae, K., Kumagai, N., Sawanobori, E., Nakazato, H., Ohtsuka, Y., Nakanishi, Tags: Clinical Epidemiology Source Type: research