The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury

Conclusions
We elucidated a novel mechanism that links TRPC6 activity to calpain-1 activation and through Talin-1 loss and possibly, calcineurin activation, the podocyte injury characterizing FSGS. Therefore, calpain-1 and/or TRPC6 inhibition could be future therapeutic options to treat patients with FSGS or other podocytopathies.

Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Verheijden, K. A. T., Sonneveld, R., Bakker-van Bebber, M., Wetzels, J. F. M., van der Vlag, J., Nijenhuis, T. Tags: Basic Research Source Type: research