The impact of luteal serum progesterone levels on live birth rates —a prospective study of 602 IVF/ICSI cycles

This study is the first to explore the possible upper and lower thresholds for luteal P4 following IVF treatment and fresh embryo transfer, and the optimal P4 ranges found in this study should be corroborated in future clinical trials. Furthermore, the P4 thresholds in this study only apply to fresh IVF cycles, using vaginal luteal phase support, as the optimal P4 level in cycles using intramuscular P4 may be different.WIDER IMPLICATIONS OF THE FINDINGSFuture studies are necessary to explore whether additional exogenous luteal P4 supplementation in the low P4 group could increase the chance of a live birth following fresh embryo transfer, and whether patients with luteal P4 levels>400 nmol/l would benefit from segmentation followed by subsequent transfer in frozen/thawed cycles.TRIAL REGISTRATION NUMBERNCT02129998 (Clinicaltrials.gov).STUDY FUNDING/COMPETING INTEREST(S)L.H.T. received an unrestricted grant from Ferring Pharmaceuticals, Denmark, to support this study. P.H. received unrestricted research grants from MSD, Merck, Gedeon Richter and Ferring Pharmaceuticals outside of this work as well as honoraria for lectures from MSD, Merck and Gedeon Richter outside of this work. U.K. received honoraria for lectures from MSD and Ferring Pharmaceuticals outside of this work. C.A. received unrestricted research grants from MSD, IBSA, and Ferring Pharmaceuticals outside of this work as well as honoraria for lectures from MSD and IBSA. H.O.E. and B.B.P. received an unrestricted ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research