Urine tricarboxylic acid (TCA) cycle metabolites predict progressive chronic kidney disease in type 2 diabetes.

Conclusions: Key TCA cycle metabolites, especially fumarate, may be involved in pathophysiologic pathway independent of traditional cardio- renal risk factors leading to CKD progression in patients with T2DM.
PMID: 30060124 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - July 27, 2018 Category: Endocrinology Authors: Liu JJ, Liu S, Gurung RL, Ching J, Kovalik JP, Tan TY, Lim SC Tags: J Clin Endocrinol Metab Source Type: research