Manganese-Enhanced Magnetic Resonance Imaging of the Myocardium

Conditions:   Ischemic Cardiomyopathy;   Dilated Cardiomyopathy;   Hypertrophic Cardiomyopathy Intervention:   Other: Mangafodipir trisodium Sponsor:   University of Edinburgh Recruiting
Source: - Category: Research Source Type: clinical trials

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AbstractCoronary artery bypass grafting improves survival in patients with ischemic cardiomyopathy, however, these patients are at high risk for morbidity and mortality. The role of viability testing to guide revascularization in these patients is unclear. Cardiac magnetic resonance imaging (CMR) has not been studied adequately in this population despite being considered a reference standard for infarct imaging. We performed a multicenter retrospective analysis of patients (n  = 154) with severe left ventricular systolic dysfunction [ejection fraction (EF)   50% viability on CMR had a 47% reduct...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
Our study aimed to comprehensively explore efficient prognostic indicators in idiopathic dilated cardiomyopathy (IDCM) patients with reduced left ventricular ejection fraction (LVEF
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Arrhythmogenic right ventricular cardiomyopathy, formerly called “arrhythmogenic right ventricular dysplasia,” is an under-recognized clinical entity characterized by ventricular arrhythmias and a characteristic ventricular pathology. Diagnosis is often difficult due to the nonspecific nature of the disease and the broad spectrum of phenotypic variations. Therefore, consensus diagnostic criteria have been developed which combine electrocardiographic, echocardiographic, cardiac magnetic resonance imaging and histologic criteria. In 1994, an international task force first proposed the major and minor diagnostic c...
Source: Cardiology in Review - Category: Cardiology Tags: Invited Review Articles Source Type: research
We present not ‐yet‐seen multimodal images of a 55‐year‐old female patient with isolated atrial amyloidosis (IAA) who clinically suffered from multiple atrial arrhythmias and heart failure symptoms with preserved left ventricular ejection fraction. We aim to show structural and functional abnormalities det ected by electrophysiological voltage mapping, cardiac magnetic resonance imaging (MRI) [cMRI; atrial strain measurements, late gadolinium enhancement (LGE) visualization], and99mTc ‐DPD scintigraphy. Bipolar voltage mapping performed during two electrophysiological procedures showed diffuse left atrial low‐v...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
Authors: Yazaki M, Nabeta T, Inomata T, Ako J Abstract A 44-year-old man diagnosed with idiopathic dilated cardiomyopathy was admitted to our hospital with acute decompensated heart failure. Seven years before this admission, the first introduction of medication resulted in left ventricular (LV) recovery, which was sustained for several years. However, the patient stopped taking his medication, resulting in worsening of the LV function. Despite the second introduction of medication, the LV function did not improve. We performed cardiac magnetic resonance imaging and an endomyocardial biopsy, which revealed the sign...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractFBN1 gene encodes for the connective tissue protein fibrillin ‐1 which can also regulate the profibrotic cytokine transforming growth factor (TGF)‐ß1. Mutations in theFBN1 gene cause Marfan syndrome (MFS), a genetic condition with defective connective tissues.FBN1 haplotypes and single nucleotide polymorphisms have also been reported to be associated with systemic sclerosis (SSc), a connective tissue disease characterized by fibrosis of multiple organs. Furthermore, the duplication of theFbn1 gene causes a SSc ‐like disease in the TsK1 mouse model. To the best of our knowledge, there are no reports of M...
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: CASE REPORT Source Type: research
AbstractCardiomyopathies are a heterogeneous entity. The progress in the field of genetics has allowed over the years to determine its origin more and more often. The classification of these pathologies has changed over the years; it has been updated with new knowledge. Imaging allows to define the phenotypic characteristics of the different forms of cardiomyopathy. Cardiac magnetic resonance (CMR) allows a morphological evaluation of the associated (and sometimes pathognomonic) cardiac findings of any form of cardiomyopathy. The tissue characterization sequences also make magnetic resonance imaging unique in its ability t...
Source: La Radiologia Medica - Category: Radiology Source Type: research
ConclusionsFinerenone administered as a monotherapy is disease modifying for both skeletal muscle and heart in a preclinical DMD model. These findings support further evaluation of finerenone in DMD clinical trials.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
We describe 5 independent Italian subjects presenting with progressive limb girdle muscular weakness, brain white matter abnormalities, merosin deficiency and LAMA2 gene mutations. We detected 7 different mutations, 6 of which are new. All patients showed normal psicomotor development and slowly progressive weakness with onset spanning from childhood to forties. Creatin-kinase levels were moderately elevated. One patient showed dilated cardiomyopathy. Muscle MRI allowed to evaluate the degree and pattern of muscular involvement in all patients. Brain MRI was fundamental in order to address and/or support the molecular diag...
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
Publication date: November 2020Source: American Heart Journal, Volume 229Author(s): Godefroy Chery, Nicholas Kamp, Andrzej S. Kosinski, Gillian Sanders Schmidler, Renato D. Lopes, Manesh Patel, Sana M. Al-Khatib
Source: American Heart Journal - Category: Cardiology Source Type: research
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