DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions

HIV-1 Env, the only target of neutralizing antibodies, is highly dynamic, and only snapshots of static conformations are available. Stadtmueller et  al. used DEER spectroscopy to map conformations of soluble Env and its complexes with antibodies or the CD4 receptor. Results reveal similarities to virion-bound Env and buried non-neutralizing antibody epitopes, advancing knowledge of Env function and vaccine design.

Source: Immunity - July 31, 2018 Category: Allergy & Immunology Authors: Beth M. Stadtmueller, Michael D. Bridges, Kim-Marie Dam, Michael T. Lerch, Kathryn E. Huey-Tubman, Wayne L. Hubbell, Pamela J. Bjorkman Tags: Article Source Type: research