The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

Scott et  al. demonstrate that ZEB2 is critical for maintaining the tissue identities of macrophages. Loss of ZEB2 results in tissue-specific changes in different macrophage populations and their subsequent disappearance. In Kupffer cells, ZEB2 maintains LXRα expression, loss of which reproduces the change in Kupffer cell identity and their disappearance.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Article Source Type: research