Smad4/DPC4.

Smad4/DPC4. J Clin Pathol. 2018 Aug;71(8):661-664 Authors: McCarthy AJ, Chetty R Abstract Smad4 or DPC4 belongs to a family of signal transduction proteins that are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor beta (TGF-β) signaling via several pathways. The gene acts as a tumour suppressor gene and inactivation of smad4/DPC4 is best recognised in pancreatic cancer. However, smad4/DPC4 is also mutated in other conditions and cancers such as juvenile polyposis syndrome with and without hereditary haemorrhagic telangiectasia, colorectal and prostate cancers.Immunohistochemistry for smad4/DPC4 protein is most useful in separating benign/reactive conditions from pancreatic cancer in needle/core biopsies. In normal and reactive states, the protein is localised to the cytoplasm and nucleus, while the protein is lost in high-grade pancreatic intraepithelial neoplasia/carcinoma in situ and pancreatic cancer. PMID: 29720405 [PubMed - indexed for MEDLINE]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Pathol Source Type: research