Prognostic significance of soluble major histocompatibility complex class I-related chain A (sMICA) in gastric cancer.

Prognostic significance of soluble major histocompatibility complex class I-related chain A (sMICA) in gastric cancer. Br J Biomed Sci. 2018 Jul 30; Authors: Xu Y, Chen D, Cheng H Abstract OBJECTIVE: Gastric cancer is a common malignancy, but there are no reliable blood markers for this disease. We tested the hypothesis of a link between serum soluble major histocompatibility complex class I-related chain A (sMICA) and clinicopathological features in gastric cancer. METHODS: A total of 196 patients who underwent gastrectomy and 120 controls (46 healthy individuals, 41 minimal gastritis, 7 gastric ulcers and 26 normal appearance of the gastric mucosa on gastroscopic examination) were enrolled. Serum levels of sMICA were assessed by ELISA. The link between sMICA and prognosis was evaluated after a minimum of 5 years follow up. RESULTS: The patients with gastric cancer had a significantly higher sMICA levels than that of the controls (mean (SD) 255 (69) versus 17 (4): P
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research

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