Important Information about Breast Implants and BIA-ALCL

ByChristine A. Hamori, MDRecent media coverage of an FDA update regarding BIA-ALCL (Breast Implant Associated Anaplastic Large Cell Lymphoma) is causing a lot of concern among breast implant patients. First of all, patients should know that BIA-ALCL is not new, and that this is a very rare disease. Also, it is only associated with textured implants. During every breast augmentation consult I do with every potential patient, we go over this information. In fact, rarely do my patients and I choose a textured implant.My colleague Dr. William Adams has published this informative update with a video from the Plastic Surgery Channel:An Update to Breast Implant-Associated ALCL.The video is below for your viewing.The bottom line, as spelled out in this report, is:" Breast Implant-Associated ALCL is not new and there is excellent research and progress in reducing its occurrence and improving the treatment should it occur.  Here ’s what patients should know:It is a rare disease that appears to be associated with TEXTURED breast implantsIf you notice significant swelling or changes in breast shape and size, call your plastic surgeonIf diagnosed and treated properly, it is curablePatients desiring breast implants should know the difference between textured and smooth implants and discuss the best option for them with their surgeon. "I also recommend this in-depth post by another colleague, Dr. Karen Horton:ALCL and Breast Implants? The Rare Incidence of Anaplastic La...
Source: What's New In Plastic Surgery? - Category: Cosmetic Surgery Tags: bia-alcl breast cancer breast implant associated anaplastic large cell lymphoma breast implants fda Source Type: blogs

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This study aimed to investigate the risk of self-harm following diagnosis of different psychiatric disorders in an Asian population, through a review of inpatient records retrieved from the Hong Kong Clinical Data Analysis and Reporting System (CDARS).MethodsFor this nested case-control study, the inpatient data of people admitted for any reason to Hong Kong public hospitals, between Jan 1, 2000, and Dec 31, 2010, were extracted from CDARS. Cases were people aged 10 years or older who had been admitted to inpatient care with a first-listed record of psychiatric disorder during the study period. The seven psychiatric disord...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
In conclusion, the addition of PPIs to the treatment regimen of breast cancer appears to be a promising strategy to potentiate the efficacy of chemotherapy and may suppress cancer metastasis. PMID: 31955147 [PubMed - in process]
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Abstract A series of nine new 2,3-disubstituted 4(3H)-quinazolin-4-one derivatives was furnished starting from the 2-propyl-4(3H)-quinazo-line-4-one (2). The reinvestigation of the key starting quinazolinone 2 was performed under microwave irradiation (MW) and solvent-free conditions. Combination of MW and phase-transfer catalysis using tetrabutylammonium benzoate (TBAB) as a novel neutral ionic catalyst was used for carrying out N-alkylation and condensation reactions of compound 2 as a simple, efficient and eco-friendly technique. The structure of the synthesized compounds was elucidated using different spectral...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
This study aims to unveil the mechanisms underlying the pro-apoptotic effect of Cur-NLC on HepG2 cells. Evidence indicates that low expression of death receptors (DRs) on cancer cell membranes leads to attenuated apoptosis signaling. This study showed that Cur-NLC significantly increased total expression of DR5 protein while simultaneously upregulated cell membrane expression of DR5. Cur-NLC significantly increased caspase-8 and caspase-3 activities, accompanied by increased apoptosis. Furthermore, enhanced apoptosis was inhibited in the presence of a pan-caspase inhibitor, Z-VAD-FMK. Therefore, Cur-NLC induced activation ...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Abstract The incidence of mortality of prostate cancer (PCa) has been an uptrend in recent years. Our previous study showed that the sex-determining region Y-box 7 (SOX7) was low-expressed and served as a tumor suppressor in PCa cells. Here, we describe the effects of polyphyllin D (PD) on proliferation and cell cycle modifications of PCa cells, and whether SOX7 participates in this process. PC-3 cells were cultured in complete medium containing PD for 12, 24, and 48 h. MTT assay was used to investigate the cytotoxic effects of PD. Cell cycle progression was analyzed using propidium iodide (PI) staining, and prote...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
(WASHINGTON) — Breast implant maker Allergan Inc. issued a worldwide recall Wednesday for textured models because of a link to a rare form of cancer. The U.S. Food and Drug Administration said it called for the removal after new information showed Allergan’s Biocell breast implants with a textured surface account for a disproportionate share of rare lymphoma cases. The move follows similar action in France, Australia and Canada. The FDA is not recommending women with the implants have them removed if they are not experiencing problems. Biocell implants feature a textured surface designed to prevent slippage and...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer onetime Source Type: news
ConclusionThe distribution of registered semiconductor workers with cancer and rare diseases was closely related to the manufacturing era prior to 2005, ≤8 inches wafer size handled, exposure to clean rooms of fab and chip assembly operations, and etching operations.
Source: Safety and Health at Work - Category: Occupational Health Source Type: research
This study proposed a pilot study of a new tool for a reliable and accurate stratification of patients with acute leukemia based on an integrative model of leukemia behavior, cell characterization, and clinical features, in addition, to an evaluation of intra-tumor and inter-tumor heterogeneity. Together our approach allows us to introduce an integrative quantitative approach to use zebrafish and tumor characterization as a prediction tool for the behavior of acute leukemia in young adults. Materials and Methods Animal Care and Handling Zebrafish wild-type (A/B and TAB5) adults were raised and maintained according to st...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONBreast lymphoma must be considered in the differential diagnosis of a breast lump, even in the presence of cutaneous inflammatory changes. PBL can be treated successfully with combined therapy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ByChristine A. Hamori, MDRecent media coverage of an FDA update regarding BIA-ALCL (Breast Implant Associated Anaplastic Large Cell Lymphoma) is causing a lot of concern among breast implant patients. First of all, patients should know that BIA-ALCL is not new, and that this is a very rare disease. Also, it is only associated with textured implants. During every breast augmentation consult I do with every potential patient, we go over this information. In fact, rarely do my patients and I choose a textured implant.My colleague Dr. William Adams has published this informative update with a video from the Plastic Surgery Cha...
Source: What's New In Plastic Surgery? - Category: Cosmetic Surgery Tags: bia-alcl breast cancer breast implant associated anaplastic large cell lymphoma breast implants fda Source Type: blogs
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