Inflammatory Hypothesis Reaches Dilated Cardiomyopathy

(MedPage Today) -- Case report shows'unprecedented clinical improvement'with an IL-1 blocker
Source: MedPage Today Rheumatology - Category: Rheumatology Source Type: news

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Yokota Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive condition caused primarily by out-of-frame mutations in the dystrophin gene. In males, DMD presents with progressive body-wide muscle deterioration, culminating in death as a result of cardiac or respiratory failure. A milder form of DMD exists, called Becker muscular dystrophy (BMD), which is typically caused by in-frame dystrophin gene mutations. It should be emphasized that DMD and BMD are not exclusive to males, as some female dystrophin mutation carriers do present with similar symptoms, generally at reduced levels of severity. Cardiac involve...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
In conclusion, the present study identified six hub genes related to DCM. Therefore, the present results may provide a potential mechanism for DCM involving these hub genes, which may serve as biomarkers for screening and diagnosis in the clinic. PMID: 32626989 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Conclusions: Our data show that novel polymorphisms affecting IL12B and IL10, but not IFNG or IL4 genes play a role in genetic susceptibility to CCC development. This might indicate that the increased Th1 differentiation and IFN-γ production associated with CCC is genetically controlled.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Bechet ’s disease (BD) is a relatively rare disease that causes recurrent oral and genital ulcers in addition to a variety of systemic manifestations. Concomitant superior-vena-cava (SVC) thrombosis and cardiac...
Source: Thrombosis Journal - Category: Hematology Authors: Tags: Case report Source Type: research
Authors: S A, R V, P C, V I Abstract Ortners syndrome is a rare cause of recurrent laryngeal nerve palsy due to cardiac causes. After the description of this syndrome by Ortner in patients with mitral stenosis, it was described by many authors in multiple other cardiac conditions. Here we present a case of Ortner's syndrome in Dilated cardiomyopathy,which reverted completely after medical management of DCMP. PMID: 32610886 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Sirico G, Montisci A, Secchi F, Mantica M Abstract A significant number of sudden death (SD) is observed in myotonic dystrophy (DM1) despite pacemaker implantation and some consider the ICD to be the preferential device in patients with conduction disease. According to the latest guidelines, prophylactic ICD implantation in patients with neuromuscular disorder should follow the same recommendations of non-ischemic dilated cardiomyopathy, being reasonable when pacing is needed. We here report a case of DM1 patient who underwent ICD implantation even in the absence of conduction disturbances on ECG and ventr...
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
Publication date: Available online 2 July 2020Source: Stem Cell ResearchAuthor(s): Sabine Rebs, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder, Katrin Streckfuss-Bömeke
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs. Heart involvement is frequent and leads to cardiolaminopathy LMNA-dependent cardiomyopathy (LMNA-CMP), a form of dilated cardiomyopathy (DCM) typically associated with conduction disorders and arrhythmias, that can manifest either as an isolated event or as part of a multisystem phenotype. Despite the recent clinical and molecular developments in the field, there is still lack of knowledge linking specific LMNA gene mutations to the distinct ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Nonischemic dilated cardiomyopathy (NICM) is characterized by dilation and loss of function in one or both ventricles. NICM may be caused by a variety of primary or secondary conditions that affect the heart such as infiltrative causes, metabolic diseases, myocarditis, medications and many more. However, an estimated 50% of NICM are idiopathic or genetic [1], and are defined as dilated cardiomyopathies (DCM). There is a growing interest in the field of molecular genetics pertaining to DCM, and many genes have been identified that may contribute to phenotypically significant cardiomyopathy [2].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Abstract BACKGROUND: The clinical characteristics and prognostic outcomes of dilated cardiomyopathy (DCM) with a familial history (FHx) via pedigree analysis are unclear.Methods and Results:We conducted a prospective observational study of 514 consecutive Japanese patients with DCM. FHx was defined as the presence of DCM in ≥1 family member within 2-degrees relative based on pedigree analysis. The primary endpoint was a composite of major cardiac events (sudden cardiac death and pump failure death). The prevalence of FHx was 7.4% (n=38). During a median follow-up of 3.6 years, 77 (15%) patients experienced ...
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
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