Tobacco influence in heavy metals levels in head and neck cancer cases.
Tobacco influence in heavy metals levels in head and neck cancer cases. Environ Sci Pollut Res Int. 2018 Jul 28;: Authors: Bandeira CM, de Almeida AÁ, Carta CFL, Almeida AA, de Figueiredo FAT, Sandrim VC, Gonçalves AJ, Almeida JD Abstract Heavy metals intoxication is known to be risk factors for various diseases, including cancer. These metals may be presented in food and soil as well as in leaf and tobacco smoke. The aim of this study was to correlate the exposure to heavy metals stemming from tobacco and head and neck squamous cell carcinoma carcinogenesis. Analysis of lead, copper, manganese, arsenic, chromium, and cadmium by atomic absorption spectrophotometry was performed in whole blood samples from 91 patients: 68 smokers with oral cavity, pharynx, or laryngeal cancer; 8 non-smokers with oral or larynx cancer; and 15 non-cancer smokers with tobacco-related diseases (control group). No differences were found in metals quantifications, except a significant difference was observed (p = 0.0223) with higher mean in copper levels for non-smokers with cancer. The present study concluded, for the groups evaluated, it was not possible to prove the relationship between the studied metals in the development of the neoplasm. On the other hand, the results of copper demonstrated a correlation with smokers with cancer and lower levels of circulating copper. PMID: 30056540 [PubMed - as supplied by publisher]
Conclusion: Our findings suggested that the SNPs (rs16879870, rs2641256, rs2761591, rs854936) might play a crucial role in prognosis of HNSCC.
Conclusions: HART represents an attractive approach for patients with HNSCC where treatment intensification is indicated. PMID: 31519130 [PubMed - as supplied by publisher]
In conclusion, we describe several SNPs associated with HNC in a Spanish population.
Transforming growth factor-β signaling in head and neck squamous cell carcinoma: Insights into cellular responses. Oncol Lett. 2018 Oct;16(4):4799-4806 Authors: Pang X, Tang YL, Liang XH Abstract Head and neck squamous cell carcinoma (HNSCC) arises in the oral cavity, salivary glands, larynx, pharynx, nasal cavity and paranasal sinuses, and is characterized by high morbidity and metastasis rates. Transforming growth factor-β (TGF-β) is a homodimeric protein known to be a multifunctional regulator in target cells and to serve a pivotal role in numerous types of cancer, including HNSCC. Th...
CONCLUSIONS: Polymorphic variant XRCC1 HNSCC patients treated with CCRT have significantly increased acute radiation morbidities and may have a trend toward better PFS in comparison with the wild variant. PMID: 29893275 [PubMed - in process]
ConclusionThis is the first described case of grade 4 immune mucositis and esophagitis associated with pembrolizumab. Because the use of pembrolizumab is increasing in oncology, pharmacists and physicians should be aware of this rare manifestation.
Head and neck squamous cell carcinoma (HNSCC) arises from a number of distinct locations in the upper aerodigestive tract, including the oral cavity, pharynx and larynx . Whilst the treatment of local disease has improved over the last few decades, locoregionally advanced disease has remained a challenge, requiring a multimodal approach of surgery and chemo/radiation therapy [2,3]. Despite intensive efforts, the global 5-year survival of HNSCC remains poor (40 –50%), although in Australia this is now in excess of 60% [4,5].
AbstractHead and neck cancer (HNC) includes a diverse range of malignancies arising commonly from mucosal epithelia of the upper aerodigestive tract. Head and neck squamous cell carcinoma (HNSCC), the most common form of HNC, develops in the oral cavity, pharynx, and larynx and is associated with tobacco exposure, alcohol abuse, and infection with oncogenic viruses. Despite global advances in cancer care, HNSCC often presents with advanced disease and is associated with poor 5-year survival of ~50%. Genotyping tumor tissue to guide clinical decision-making is becoming commonplace in modern oncology, but in the management o...
Ninety percent of head and neck cancers are squamous cell carcinomas involving mucosal surfaces of the oral cavity, pharynx, and larynx. This cancer can affect any site in the oral mucosa, typically the tongue and floor of the mouth . Oral squamous cell carcinoma (OSCC), a subset of head and neck squamous cell carcinoma, is one of the most common human malignancies worldwide [2,3]. Further, OSCC is the most common malignant tumor of the head and neck, and its incidence has increased in recent years .
Head and neck squamous cell carcinoma (HNSCC), which comprises cancer of the oral cavity, pharynx and larynx, is the 6th leading malignancy worldwide. With a reported annual burden of 633,000 incident cases, 355,000 deaths, and a 5year overall survival rate ∼60%, patient prognosis remains poor as diagnosis often occurs late into disease progression when advanced stage cancer is unresponsive to therapy [1–3]. Established risk factors for HNSCC include tobacco use and alcohol consumption . Human Papilloma Virus (HPV) status has also been identifie d as a risk factor for HNSCC [5,6].