Diffuse brainstem gliomas: MRI

Case Report: This is a pediatric case of diffuse intrinsic pontine gliomas with enlargement of the pons, with the basilar artery displaced anteriorly against the clivus . The floor of the fourth ventricle is flattened, this is called as flat floor of fourth ventricle sign and obstructive hydrocephalus may be present. There is only minimal post gadolinium enhancement in post contrast scans. Diffuse intrinsic pontine gliomas harbour K27M mutations in the histone H3 gene H3F3A, or less commonly in the related HIST1H3B genes.Famous Radiology Blog http://www.sumerdoc.blogspot.com
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Source: Sumer's Radiology Site - July 30, 2018 Category: Radiology Authors: Sumer Sethi Source Type: blogs