"We are guinea pigs": New documentary explores risks of medical devices

"The Bleeding Edge" filmmakers speak with patients suffering apparent complications from cobalt hip replacements and the Essure permanent birth control device
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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Publication date: Available online 18 April 2019Source: Blood Cells, Molecules, and DiseasesAuthor(s): Livia Hegerova, Fiona He, Nicole D. Zantek, Gregory M. Vercellotti, Shernan G. Holtan, Mark T. RedingAbstractAcquired von Willebrand syndrome (AVWS) is a rare, potentially fatal bleeding disorder caused by low activity of von Willebrand factor (VWF) in patients without congenital deficiency. The majority of adult cases are associated with hematological malignancy, including lymphoproliferative (48%) or myeloproliferative (15%) disorders (Federici et al., 2000). Both qualitative and quantitative defects occur, due to antib...
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
ConclusionsIn patients with ACS, ticagrelor is more efficacious in protecting against new ischemic events and mortality than clopidogrel, irrespective of the presence of HF. There is no difference between ticagrelor or clopidogrel treatment in new-onset HF post-ACS.
Source: American Heart Journal - Category: Cardiology Source Type: research
Initial clinical results suggest that the new agent may be suitable for use with thrombolysis in acute ischemic stroke.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
THURSDAY, April 18, 2019 -- Researchers say an experimental stroke drug prevented blood clots without the typical side effect of blood thinners: increased bleeding risk. Bleeding is a common and potentially dangerous side effect of current...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
CONCLUSIONS: Our findings expand the mutational spectrum of HPS, which may help in investigating phenotype-genotype relationships and assist genetic counselling for affected individuals. This approach is a proof of principle that HTS can be considered and used in the first-line diagnosis of patients with biological and clinical manifestations suggestive of HPS. Key messages We established the relationships between the clinical and laboratory phenotype and genotype of six unrelated pedigrees comprising ten patients with clinical suspicion of HPS. Molecular analysis is useful in confirming the diagnosis and may offer some pr...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Publication date: Available online 17 April 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Michael Sai Lai Sey, Brian Michael YanAbstractThe management of small bowel bleeding, also known as obscure gastrointestinal bleeding, has changed substantially over the past two decades due to revolutionary technological advances in small intestinal endoscopy. This clinical review will summarize the evolving definition of small bowel bleeding, how to perform a detailed initial assessment of patients with the condition, the strengths and limitations of small bowel endoscopy, and the treatment of small bowel bleeding.
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 17 April 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Pablo Cañamares, Francis K.L. ChanAbstractEndoscopic therapy is the mainstay of treatment for nonvariceal upper gastrointestinal bleeding (NVUGIB). Injection plus mechanical or thermal therapy continues to be the most widely used option. New endoscopic devices such as the use of an inert powder or a new class of over-the-scope clip system have demonstrated encouraging results as a rescue therapy for difficult hemostasis. Emerging data suggest that Doppler ultrasound- guided endoscopic therapy may i...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 17 April 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Dr Kathryn OaklandABSTRACTRisk assessment is widely used in upper gastrointestinal bleeding (UGIB) however no score accurately predicts all important clinical outcomes. This review discusses the performance of the Rockall score, pre-endsocopy Rockall score, Glasgow-Blatchford score, AIMS-65 and newer scores such as Progetto Nazionale Emorragia Digestiva and CANUKA scores. The quality of external validation varies considerably for each score. There is a relative lack of risk scores available for use in low...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 17 April 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Romaric Loffroy, Nicolas Falvo, Motoki Nakaï, Lorenzo Pescatori, Marco Midulla, Olivier ChevallierAbstractAlthough most cases of acute nonvariceal gastrointestinal bleeding (GIB) either spontaneously resolve or respond to medical management and endoscopic therapy, there are still a significant proportion of severe patients who require emergency angiography and endovascular treatment. Over the past three decades, transcatheter arterial embolization (TAE) has become the first-line therapy for the manag...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 17 April 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Kathryn OaklandAbstractUpper gastrointestinal bleeding (UGIB) develops in the oesophagus, stomach or duodenum and has an incidence of 47/100,000. Lower GIB (LGIB) develops in the small bowel, colon or anorectum and has an incidence of 33/100,000. Where the incidence of UGIB has fallen, driven by helicobacter pylori eradication and the use of proton pump inhibitors, the incidence of LGIB may be increasing. Interventions such as early endoscopy, risk assessment and national guidelines have improved clinical...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
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