"We are guinea pigs": New documentary explores risks of medical devices

"The Bleeding Edge" filmmakers speak with patients suffering apparent complications from cobalt hip replacements and the Essure permanent birth control device
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†. Drug Deliv. 2018 Nov;25(1):1672-1682 Authors: Salem AE, Mohamed EA, Elghadban HM, Abdelghani GM Abstract To treat anal fissure, internal anal sphincterotomy may be associated with surgical risks and incidence of incontinence. Botulinum toxin injection into the anal sphincter is invasive and expensive. Headache and hypotension hindered topical treatment with glyceryl trinitrate. Greater patient compliance, potentiated efficacy, reduced side effects, and lower cost are the major advantages offered ...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Caspers M, Maegele M, Fröhlich M Abstract INTRODUCTION: Despite advances in the treatment of severely injured patients that have resulted in overall improved outcomes, uncontrolled hemorrhage still represents the most common cause of preventable death following major injury. While addressing both endo- and exogenous factors that lead to an acute trauma-induced coagulopathy, massive transfusion plays a key role in managing bleeding trauma patients. However, the best practice for hemostatic control including massive transfusion in these patients is still under debate. Areas covered: This review summariz...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
ConclusionIn this large observational series, we did not detect an association between paralytic choice and first-pass rapid sequence intubation success or peri-intubation adverse events.
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
Publication date: Available online 16 November 2018Source: International Journal of Surgery Case ReportsAuthor(s): Catarina Melo, Carolina Canhoto, Fernando Manata, António BernardesAbstractIntroductionGastrointestinal stromal tumors represent about 1% of the tumors of digestive tract. Their presentation consists often of indolent symptoms. However, they can present as surgical emergencies in rare cases. This work presents a case of a giant jejunal GIST that required emergent surgical treatment.Case presentationA 60-year-old male presented with abdominal pain and acute low gastrointestinal bleeding. During observati...
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Most anterior epistaxis originates primarily from the Kiesselbach plexus, whereas posterior epistaxis is less common and originates from branches of the sphenopalatine artery. Risk factors include local trauma, foreign body insertion, substance abuse, neoplasms, inherited bleeding diatheses, or acquired coagulopathies. Assessment of airway, breathing, and circulation precedes identification of bleeding source, pain control, and achieving hemostasis. Management options include topical vasoconstrictors, direct pressure, cautery, tranexamic acid, nasal tampons, Foley catheters, or surgical intervention. Specialty consultation...
Source: Emergency Medicine Clinics of North America - Category: Emergency Medicine Authors: Source Type: research
In conclusion, most patients had achieved the target INR at the time of ICH, and the primary precipitant of fatal ICH was often a fall. Using DOACs instead of warfarin and implementing structured fall-prevention programs in high-risk patients could further reduce mortality from ICH in AF.
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
In this study of admissions for acute PE, comorbid cancer was associated with decreased odds of receiving thrombolysis. As PE is a common complication among patients with cancer, the risk–benefit profile of thrombolysis in this patient population should be determined.
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
This study examined potential differences in bleeding between apixaban and rivaroxaban, the most commonly utilized direct oral anticoagulants at the Richard L. Roudebush VA Medical Center. Additionally, the analysis included a comparison between observed and literature-reported bleeding rates. This retrospective chart review examined 452 (39%) Veterans receiving rivaroxaban and 716 (61%) Veterans receiving apixaban. Bleeding rates were expressed per 100 patient-years and the overall rates were analyzed as the primary analysis. Secondary objectives included comparisons based on indication and severity, as well as comparison...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
The article Andexanet alfa in the treatment of acute major bleeding related to apixaban and rivaroxaban: a profile of its use in the USA, written by Young-A Heo, was originally published Online First without open access.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Yaxin Wang, Yajun Li, Xiangwei Meng, Xiumei Duan, Meilan Wang, Wenqing Chen, Tongyu Tang, Yuqin Li
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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