The Woman With Multiple Sclerosis and Blurry Vision The Woman With Multiple Sclerosis and Blurry Vision

Why is this 65-year-old patient with relapsing-remitting MS having decreased vision in her right eye?Medscape Ophthalmology
Source: Medscape Ophthalmology Headlines - Category: Opthalmology Tags: Ophthalmology Case Challenge Source Type: news

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Publication date: Available online 15 July 2019Source: NeuroImage: ClinicalAuthor(s): Mário João Fartaria, Tobias Kober, Cristina Granziera, Meritxell Bach CuadraAbstractPurposeThe goals of this study were to assess the performance of a novel lesion segmentation tool for longitudinal analyses, as well as to validate the generated lesion progression map between two time points using conventional and non-conventional MR sequences.Material and methodsThe lesion segmentation approach was evaluated with (LeMan-PV) and without (LeMan) the partial volume framework using “conventional” and “non-conv...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
The migration of leukocytes into the CNS drives the neuropathology of multiple sclerosis (MS). It is likely that this penetration utilizes energy resources that remain to be defined. Using the experimental autoimmune encephalomyelitis (EAE) model of MS, we determined that macrophages within the perivascular cuff of postcapillary venules are highly glycolytic, as manifested by strong expression of lactate dehydrogenase A (LDHA), which converts pyruvate to lactate. These macrophages expressed prominent levels of monocarboxylate transporter-4 (MCT-4), which is specialized in the secretion of lactate from glycolytic cells. The...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ABSTRACT Multiple sclerosis (MS) is an autoimmune, inflammatory, and degenerative disease of the central nervous system. Axonal degeneration is triggered by inflammation and is the pathological substrate of progressive disability in patients with MS. Therapeutic interventions can reduce inflammatory activity, thus delaying neurodegeneration and the progression of disability. Disease activity and neurodegeneration are assessed mainly through clinical evaluation and magnetic resonance imaging. These measures lack sensitivity and accuracy, so new biomarkers are necessary. Several markers have been studied and to date the most...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
ConclusionsLow levels of openness and extroversion traits are associated with a greater risk of developing time-based PM deficit. Therefore, personality assessment and behavioural interventions should be encouraged in MS clinical practice.
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractAlzheimer ’s disease (AD), the most common cause of dementia remains of unclear etiology with current pharmacological therapies failing to halt disease progression. Several pathophysiological mechanisms have been implicated in AD pathogenesis including amyloid-β protein (Aβ) accumulation, tau hyperphospho rylation, neuroinflammation and alterations in bioactive lipid metabolism. Sphingolipids, such as sphingosine-1-phosphate (S1P) and intracellular ceramide/S1P balance are highly implicated in central nervous system physiology as well as in AD pathogenesis. FTY720/Fingolimod, a structural sphingosin...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research
AbstractMultiple sclerosis (MS) more than any other neurological disorder has experienced a tremendous progress in available evidence-based innovator disease modifying therapies (DMT). These medications include injectable complex nonbiological drugs (CNBD), the injectable biological products β-interferons-1a and -1b, and the infusible monoclonal antibodies (MAB), as well as oral synthetic therapeutic molecules. The degree of efficacy and adverse effects profile is variable. By the end of 2019, all medications have been approved for relapsing forms of MS, including five with indication for clinically isolated syndrome ...
Source: Neurology and Therapy - Category: Neurology Source Type: research
Conclusions: A calendar with CW was non-inferior than FR at the beginning of IFN-b therapy, and may not affect the long-term outcome. Clinicaltrial.gov identifiers: NCT00270816
Source: Frontiers in Neurology - Category: Neurology Source Type: research
MONDAY, July 15, 2019 -- Obesity seems to be associated with increased odds of pediatric multiple sclerosis (MS), according to a study published online July 15 in JAMA Neurology. Brenda Huppke, M.D., from the University Medical Center G öttingen in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
LOS ANGELES (AP) — Scientists are closing in on a long-sought goal — a blood test to screen people for possible signs of Alzheimer’s disease and other forms of dementia. On Monday at the Alzheimer’s Association International Conference, half a dozen research groups gave new results on various experimental tests, including one that seems 88% accurate at indicating Alzheimer’s risk. Doctors are hoping for something to use during routine exams, where most dementia symptoms are evaluated, to gauge who needs more extensive testing. Current tools such as brain scans and spinal fluid tests are too ex...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Alzheimer's Disease Dementia Source Type: news
This study examines whether high body mass index in children and adolescents is a factor in the onset of multiple sclerosis and in treatment response.
Source: JAMA Neurology - Category: Neurology Source Type: research
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