Prognostic impact of residual HPV ctDNA detection after chemoradiotherapy for anal squamous cell carcinoma.

CONCLUSIONS: This is the first proof of concept study assessing the prognostic value of ctDNA after CRT in locally advanced ASCC. In most patients, HPV ctDNA can be detected before CRT and becomes undetectable during CRT. In the present study, we show that residual ctDNA levels after CRT are associated with very poor outcome. PMID: 30054279 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30054279?dopt=Abstract

Source: Clinical Cancer Research - July 27, 2018 Category: Cancer & Oncology Authors: Cabel L, Jeannot E, Bièche I, Vacher S, Callens C, Bazire L, Morel A, Bernard-Tessier A, Chemlali W, Schnitzler A, Lièvre A, Otz J, Minsat M, Vincent-Salomon A, Pierga JY, Buecher B, Mariani P, Proudhon C, Bidard FC, Cacheux W Tags: Clin Cancer Res Source Type: research