Synthesis and characterization of triruthenium carbonyl incorporating 4-pyridones as potential antitumor agents

Publication date: Available online 29 July 2018Source: Journal of Organometallic ChemistryAuthor(s): V.D. Reddy, Divya Dayal, David J. Szalda, Stephen C. Cosenza, M.V. Ramana ReddyAbstractFour new organometallic triruthenium carbonyl incorporating 4-pyridones: [Ru3(CO)8(2L-2H)] (1, L = N-benzyl-3-hydroxy-2-methyl-4-pyridone; 2, L = 3-hydroxy-2-methyl-N-phenyl-4-pyridone; 3, L = 3-hydroxy-N,2-dimethyl-4-pyridone; 4, L = 2-methyl-4-pyridone) were synthesized and characterized. Proton NMR spectrum of 1 shows doublets for the two-nonequivalent benzylic hydrogens due to restricted rotation around C-N bond upon bonding to Ru(2)---Ru(3) as opposed to a singlet in the unbound N-benzyl-3-hydroxy-2-methyl-4-pyridone. Compounds 1 and 3 were characterized by X-ray diffraction analyses. Compounds 1 and 3 consists of two ruthenium-ruthenium bonds Ru(1)-Ru(2), Ru(1)-Ru(3) and a non-bonded separation of two ruthenium atoms defined by Ru(2) … Ru(3), which is bridged by two 3 electron donar oxygen atoms through two-pyridinonato ligands above and below triruthenium plane, and 8 terminal CO groups. Atoms Ru(2) and Ru(3) ligated by two CO ligands each and Ru(1) with four. Antitumor activity of the compounds 1–4 has been evaluated against five types of human cancer cell lines. Compounds 1 and 2 show excellent antitumor activity due to lipophilic nature of N-substituted arene pyridinonato ligands than compounds. Structure-activity studies show that there is a correlation between...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research