Time-kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile.

CONCLUSION: The data presented here demonstrate the potent in vitro bactericidal activity of cadazolid against different ribotypes of C. difficile, although on a limited set of strains. PMID: 30052178 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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Clostridioides difficile (formerly Clostridium) causes a potentially life-threatening diarrhoea, which is acquired predominantly in hospitals. The incidence of infections caused by this organism has increased markedly over the past 20 years, although the incidence has fallen in the UK since a peak about 10 years ago. Suspicion of the condition should be high, and cases should be managed appropriately. Initiation of early treatment and rapid confirmation of diagnosis are critical to the management of C.
Source: Medicine - Category: Internal Medicine Authors: Tags: Prevention and control of infection Source Type: research
Background: Clostridioides difficile , as the main cause of infectious diarrhoea in hospitalised patients, is a considerable challenge for medical personnel (hospital environment) who have direct contact with the patient, as well as being of interest to public health specialists. Financial issues related to the occurrence of the above-mentioned micro-organism are being increasingly raised. Due to the scale of the phenomenon, we are beginning to pay attention to the significant system costs caused by the diagnosis and treatment of CDI infection and its complications. Studies indicate that the nosocomial infection of C. diff...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
arczak Background: Clostridioides difficile, as the main cause of infectious diarrhoea in hospitalised patients, is a considerable challenge for medical personnel (hospital environment) who have direct contact with the patient, as well as being of interest to public health specialists. Financial issues related to the occurrence of the above-mentioned micro-organism are being increasingly raised. Due to the scale of the phenomenon, we are beginning to pay attention to the significant system costs caused by the diagnosis and treatment of CDI infection and its complications. Studies indicate that the nosocomial infection ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This study is registered with ClinicalTrials.gov, NCT02865616 FINDINGS: Between Sept 19, 2018, and Feb 28, 2020, we enrolled 19 adult patients with at least two episodes of mild to moderate C difficile infection (median age 65 years [IQR 56-67]; 12 women [63%], seven men [37%]). Recurrent C difficile infection was absent at day 40 in 15 (79%) of 19 patients after initial treatment, increasing to 18 (95%) 40 days after retreatment. No mortality associated with C difficile infection, infections associated with MET-2 treatment, or other serious adverse events were observed. The most common self-limited, mild to moderate sympt...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conclusion. Our results showed that C. difficile toxins, including CDT, enhanced macrophage-mediated CXCL2 and TNF-α production via TLR2 and TLR4, indicating that CDT affects host immune responses.PMID:33830910 | DOI:10.1099/jmm.0.001342
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
CONCLUSION: In PICU patients with mild to moderate organ dysfunction, omeprazole does not seem to be useful for prevention of gastrointestinal bleeding while at the same time increasing the risk of CLABSI. Thus, we recommend restricting SUP to mechanically ventilated children.PMID:33685825 | DOI:10.1016/j.anpedi.2020.12.023
Source: Anales de Pediatria - Category: Pediatrics Authors: Source Type: research
ConclusionMultidrug-resistant C. difficile strains were a significant cause of healthcare facility-onset C. difficile infections in patients with prior antimicrobial exposure in this Kenyan hospital.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
The two-step, POCT strategy was estimated to save £ 283,282 per 1000 hospitalized NHS patients with suspected infectious diarrhoea. Sensitivity analysis indicated that the turnaround time for the POCT was the largest driver for cost savings. Providing the POCT has sufficiently high diagnostic accuracy for detecting C. difficile, the two-step, POCT strategy for CDI identification is likely to be cost saving for NHS hospitals with an offsite laboratory.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Abstract Clostridioides difficile (C. difficile) is the most common cause of nosocomial antibiotic associated diarrhoea. The incidence of C. difficile infection (CDI) has been rising worldwide over the last 20 years with consequent rises in morbidity, mortality and healthcare costs, although the incidence has fallen in the UK over the last few years. Confirmation of diagnosis and early intervention are critical to the management of CDI. The standard treatment for CDI is the administration of antibiotics. However, vaccination has been recognized as the most cost-effective treatment for the prevention and possible...
Source: Journal of Immunological Methods - Category: Allergy & Immunology Authors: Tags: J Immunol Methods Source Type: research
ConclusionThis study demonstrates the safety and efficacy of FMT as first-line treatment for patients ’ initial episode of CDI. Future randomised studies are required to confirm FMT as the initial treatment for CDI.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
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