Clinical assessment and treatment of diabetes in patients with chronic kidney disease

Publication date: August–September 2018Source: Revista Clínica Española (English Edition), Volume 218, Issue 6Author(s): J. Carretero Gómez, J.C. Arévalo LoridoAbstractDiabetes mellitus type 2 is the main cause of chronic kidney disease. Patients with this disease have higher morbidity and mortality and risk of hypoglycaemia than those without this disease. In 2010, type 2 diabetes was the reason for starting renal replacement therapy in 24.7% of patients. The prevalence of microalbuminuria, proteinuria and a reduced glomerular filtration rate is 36%, 8% and 22%, respectively. The presence of albuminuria is a predictor of chronic kidney disease. Diabetic kidney disease, previously known as diabetic nephropathy, refers to kidney disease caused by diabetes. Renal hyperfiltration is a marker of intraglomerular hypertension and a risk factor for onset and progression. The new antidiabetic drugs, mainly dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter inhibitors and glucagon-like peptide-1 agonists, have been shown to prevent or slow the progression of kidney disease.ResumenLa diabetes mellitus tipo 2 es la principal causa de enfermedad renal crónica. Estos pacientes presentan mayor morbimortalidad y riesgo de hipoglucemias que el resto. En 2010, la diabetes tipo 2 fue causa del inicio de terapia renal sustitutiva en el 24,7% de los pacientes. La prevalencia de microalbuminuria, proteinuria y disminución del ...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research

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CONCLUSION:: To conclude, the outcomes of radiocephalic arteriovenous fistulas created by nephrologists are at par with historic outcomes. PMID: 30784345 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
HIGH blood pressure symptoms can include chest pain, headaches, and feeling very tired. But you could also reveal your risk of deadly hypertension symptoms by checking your urine after using the toilet. This is the colour of wee you should never ignore.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The effect of meal on blood glucose concentration is a key issue in diabetes mellitus because its estimation could be very useful in therapy decisions. In the case of type 1 diabetes mellitus (T1DM), the therapy based on automatic insulin delivery requires a closed-loop control system to maintain euglycaemia even in the postprandial state. Thus, the mathematical modelling of glucose metabolism is relevant to predict the metabolic state of a patient. Moreover, the eating habits are characteristic of each person, so it is of interest that the mathematical models of meal intake allow to personalise the glycaemic state of the ...
Source: IET Systems Biology - Category: Biology Source Type: research
DIABETES type 2 risk could be lowered by making some diet or lifestyle changes. You could prevent high blood sugar symptoms and signs by making these small changes to your usual Chinese or Indian takeaway order.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
An MIT-led research team has developed a drug capsule -- about the size of a blueberry -- that could be used to deliver oral doses of insulin, potentially replacing the injections that people with Type 1 diabetes have to give themselves every day. In tests in animals, the researchers showed that ...This is an NSF Multimedia Gallery item.
Source: NSF Multimedia Gallery - Category: Science Source Type: video
Authors: Sunohara M, Kriz W, Kränzlin B, Kretzler M, Gretz N, Endlich K, Endlich N Abstract Elevated mechanical stress in glomerular hypertension is thought to damage podocytes, the loss of which leads to development of glomerulosclerosis. Applying cDNA array analysis to mechanically stressed podocytes, we have recently identified TSG101 as a stretch-induced candidate gene among others. TSG101, which is part of the ESCRT-I complex, is involved in multivesicular body (MVB) formation. Here we demonstrate that TSG101 mRNA is strongly upregulated in conditionally immortalized mouse podocytes by cyclic mechanical s...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Authors: Li Y, Yang H, Wang Y, Bu S Abstract Diclofenac sodium (DS) was the third generation non-steroidal drugs with analgesic and antipyretic properties. Owing to taking action faster, long lasting potency, good efficacy and low side effects, DS was widely used in the pharmaceutical industry. To further ensure animal food safety and consumer health, the rational usages regulations of DS and DS withdrawal time should be provided. In the present study, a new high performance liquid chromatography tandem mass spectrometry (HPLC/MS) method was first established for extracting and validating diclofenac sodium levels i...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Ruifeng Shi, Yanping Wang, Xiaofei An, Jianhua Ma, Tongzhi Wu, Xiaojin Yu, Su Liu, Liji Huang, Lijuan Wang, Jingshun Liu, Jing Ge, Shanhu Qiu, Han Yin, Xiaolai Wang, Yao Wang, Bingquan Yang, Jiangyi Yu, Zilin Sun
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 24 July 2018Source: Molecular Genetics and MetabolismAuthor(s): Meryl Waldman, Joan C. Han, Daniela P. Reyes-Capo, Joy Bryant, Kathryn A. Carson, Baris Turkbey, Peter Choyke, Jürgen K. Naggert, William A. Gahl, Jan D. Marshall, Meral Gunay-AygunAbstractAlström Syndrome is a ciliopathy associated with obesity, insulin resistance/type 2 diabetes mellitus, cardiomyopathy, retinal degeneration, hearing loss, progressive liver and kidney disease, and normal cognitive function. ALMS1, the protein defective in this disorder, localizes to the cytoskeleton, microtubule organizing center,...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Abstract There is tremendous interest in the protein dipeptidyl peptidase 4 (DPP4) as a target in diabetes management and reduction of associated cardiovascular risk. The underlying reasons for this burgeoning interest are manifold. First, DPP4 inhibitor therapy in patients with Type 2 diabetes mellitus (T2DM) resulted in a reduction in proteinuria in the recently concluded "Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus - Thrombolysis in Myocardial Infarction 53" (SAVOR-TIMI 53) trial. Second, pharmacological as well as genetic inhibition of DPP4 has proven effec...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
More News: Chronic Kidney Disease | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology | Hypertension | Proteinuria | Sodium | Urology & Nephrology