Clinical assessment and treatment of diabetes in patients with chronic kidney disease

Publication date: August–September 2018Source: Revista Clínica Española (English Edition), Volume 218, Issue 6Author(s): J. Carretero Gómez, J.C. Arévalo LoridoAbstractDiabetes mellitus type 2 is the main cause of chronic kidney disease. Patients with this disease have higher morbidity and mortality and risk of hypoglycaemia than those without this disease. In 2010, type 2 diabetes was the reason for starting renal replacement therapy in 24.7% of patients. The prevalence of microalbuminuria, proteinuria and a reduced glomerular filtration rate is 36%, 8% and 22%, respectively. The presence of albuminuria is a predictor of chronic kidney disease. Diabetic kidney disease, previously known as diabetic nephropathy, refers to kidney disease caused by diabetes. Renal hyperfiltration is a marker of intraglomerular hypertension and a risk factor for onset and progression. The new antidiabetic drugs, mainly dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter inhibitors and glucagon-like peptide-1 agonists, have been shown to prevent or slow the progression of kidney disease.ResumenLa diabetes mellitus tipo 2 es la principal causa de enfermedad renal crónica. Estos pacientes presentan mayor morbimortalidad y riesgo de hipoglucemias que el resto. En 2010, la diabetes tipo 2 fue causa del inicio de terapia renal sustitutiva en el 24,7% de los pacientes. La prevalencia de microalbuminuria, proteinuria y disminución del ...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research

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Conclusions:In a middle-aged population-based cohort, the prevalence of a RERA index≥ 5 events/h was low (3.8%) and was not associated with negative clinical outcomes when using the currently recommended scoring criteria of the American Academy of Sleep Medicine.Citation:Ogna A, Tobback N, Andries D, Preisig M, Vollenweider P, Waeber G, Marques-Vidal P, Rubio JH, Heinzer R. Prevalence and clinical significance of respiratory effort-related arousals in the general population.J Clin Sleep Med. 2018;14(8):1339–1345.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
We describe an 8-year-old male with a pathogenicUNC80 mutation, intellectual disability, hypotonia and epilepsy with severe central sleep apnea (213.5 events/h) on polysomnography (PSG). We also describe a 20-month-old female with aKCNJ11 mutation, neonatal diabetes and developmental delay who had severe central sleep apnea (131.1 events/h). Both patients had irregular respiratory patterns during sleep and wakefulness and were placed on empiric bilevel positive airway pressure therapy, which was well tolerated with resolution of abnormal respiratory control and hypercapnia. Patients withUNC80 andKCNJ11 gene mutations may h...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
In conclusion, we have demonstrated AE has benefits to regulate DPP-4 and GLP-1R, to reduce oxidative stress and renal fibrosis, with resultant to improve renal function and prevent diabetic renal damage. Taken together, F2 could be more promising to be developed as adjuvant for diabetic nephropathy.Graphical abstract
Source: Journal of Food and Drug Analysis - Category: Food Science Source Type: research
Capillary Biomedical Inc. has raised $2.9 million in a seed funding that will help it bring its diabetes management technology to market. The round was led by the Cove Fund with participation by a syndicate of Angel Groups and accredited investors. Irvine, California-based Capillary Biomedical said it plans to use the funds for clinical studies to support regulatory clearance and preparation for commercial launch in 2019. CapBio i s developing a novel infusion set for use with insulin pumps for…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 14 August 2018Source: Life SciencesAuthor(s): Leônidas Graças Mendes-Junior, Leandro Ceotto Freitas-Lima, Janaína Ribeiro Oliveira, Marcos B. Melo, Carlos Eduardo Mendes D'Angelis, Jonh David Feltenberger, Igor Viana Brandi, Bruna Mara Aparecida Carvalho, André Luiz Sena Guimarães, Alfredo Maurício Batista De Paula, Carlos Eduardo Mendes D'Angelis, Maria José Campagnole-Santos, Robson Augusto Souza Santos, Valdir Andrade Braga, Sérgio Henrique Sousa SantosAbstractDiabetic cardiomyopathy (DC) describes diabetes-associated changes in th...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 14 August 2018Source: Heart &LungAuthor(s): Dong Kyu Oh, Jong-Min Song, Duk-Woo Park, Sang Young Oh, Jin-Sook Ryu, Jaewon Lee, Sang Do Lee, Jae Seung LeeAbstractBackgroundAlthough guidelines have recommended that patients with chronic thromboembolic pulmonary hypertension (CTEPH) should be managed by a multidisciplinary team (MDT), there is a lack of clinical data indicating that the MDT improves CTEPH management.ObjectivesThe study aimed to identify the effect of an MDT on CTEPH management.MethodsWe divided the study period into pre-MDT and post-MDT eras and compared the implementati...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
AbstractTo characterize the morphological change in the right ventricle (RV) of patients with pulmonary artery hypertension (PAH) and further explore the correlation between septomarginal trabeculation (SMT) and right ventricular (RV) function, myocardial fibrosis, and exercise capacity in patients with PAH. Sixty untreated PAH patients were prospectively included from May 2016 to April 2017. All patients underwent comprehensive clinical evaluation and cardiac magnetic resonance (CMR). The area and diameter of the basal segment of SMT, and the mass of SMT were measured on cine SSFP images. Relationship between parameters o...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
Authors: Ho JS, Chilvers ER, Thillai M Abstract INTRODUCTION: Sarcoidosis is a multisystem granulomatous disease predominantly affecting the lungs, with increased risk of cardiovascular disease, pulmonary hypertension and cardiac sarcoidosis (CS), the latter due to direct granuloma infiltration. Sarcoidosis is often managed by chest physicians who need to understand the diagnostic pathways and initial management plans for patients with cardiac involvement. Areas covered: The most serious consequence of CS is sudden cardiac death due to ventricular tachyarrhythmias or complete atrioventricular block. Additional comp...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Publication date: Available online 24 July 2018Source: Molecular Genetics and MetabolismAuthor(s): Meryl Waldman, Joan C. Han, Daniela P. Reyes-Capo, Joy Bryant, Kathryn A. Carson, Baris Turkbey, Peter Choyke, Jürgen K. Naggert, William A. Gahl, Jan D. Marshall, Meral Gunay-AygunAbstractAlström Syndrome is a ciliopathy associated with obesity, insulin resistance/type 2 diabetes mellitus, cardiomyopathy, retinal degeneration, hearing loss, progressive liver and kidney disease, and normal cognitive function. ALMS1, the protein defective in this disorder, localizes to the cytoskeleton, microtubule organizing center,...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Abstract There is tremendous interest in the protein dipeptidyl peptidase 4 (DPP4) as a target in diabetes management and reduction of associated cardiovascular risk. The underlying reasons for this burgeoning interest are manifold. First, DPP4 inhibitor therapy in patients with Type 2 diabetes mellitus (T2DM) resulted in a reduction in proteinuria in the recently concluded "Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus - Thrombolysis in Myocardial Infarction 53" (SAVOR-TIMI 53) trial. Second, pharmacological as well as genetic inhibition of DPP4 has proven effec...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
More News: Chronic Kidney Disease | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology | Hypertension | Proteinuria | Sodium | Urology & Nephrology