An axonal stress response pathway: degenerative and regenerative signaling by DLK.

An axonal stress response pathway: degenerative and regenerative signaling by DLK.
Curr Opin Neurobiol. 2018 Jul 24;53:110-119
Authors: Asghari Adib E, Smithson LJ, Collins CA
Abstract
Signaling through the dual leucine zipper-bearing kinase (DLK) is required for injured neurons to initiate new axonal growth; however, activation of this kinase also leads to neuronal degeneration and death in multiple models of injury and neurodegenerative diseases. This has spurred current consideration of DLK as a candidate therapeutic target, and raises a vital question: in what context is DLK a friend or foe to neurons? Here, we review our current understanding of DLK's function and mechanisms in regulating both regenerative and degenerative responses to axonal damage and stress in the nervous system.
PMID: 30053694 [PubMed - as supplied by publisher]

Source: Current Opinion in Neurobiology - July 24, 2018 Category: Neurology Authors: Asghari Adib E, Smithson LJ, Collins CA Tags: Curr Opin Neurobiol Source Type: research