Cellular mechanisms and signals that coordinate plasma membrane repair.

Cellular mechanisms and signals that coordinate plasma membrane repair.
Cell Mol Life Sci. 2018 Jul 26;:
Authors: Horn A, Jaiswal JK
Abstract
Plasma membrane forms the barrier between the cytoplasm and the environment. Cells constantly and selectively transport molecules across their plasma membrane without disrupting it. Any disruption in the plasma membrane compromises its selective permeability and is lethal, if not rapidly repaired. There is a growing understanding of the organelles, proteins, lipids, and small molecules that help cells signal and efficiently coordinate plasma membrane repair. This review aims to summarize how these subcellular responses are coordinated and how cellular signals generated due to plasma membrane injury interact with each other to spatially and temporally coordinate repair. With the involvement of calcium and redox signaling in single cell and tissue repair, we will discuss how these and other related signals extend from single cell repair to tissue level repair. These signals link repair processes that are activated immediately after plasma membrane injury with longer term processes regulating repair and regeneration of the damaged tissue. We propose that investigating cell and tissue repair as part of a continuum of wound repair mechanisms would be of value in treating degenerative diseases.
PMID: 30051163 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - July 26, 2018 Category: Cytology Authors: Horn A, Jaiswal JK Tags: Cell Mol Life Sci Source Type: research