OCT angiography and evaluation of the choroid and choroidal vascular disorders

Publication date: Available online 27 July 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Enrico Borrelli, David Sarraf, K. Bailey Freund, Srinivas R. SaddaAbstractThe recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded our knowledge of the choroid through in vivo investigation of the anatomical and pathological features of this important vascular layer. New insights elucidating the morphological features of the choroid, in both physiological and pathological conditions, indicate that this vascular structure plays a crucial role in many chorioretinal disorders. In this article, a review of the salient histological and anatomical features of the choroid, essential for the proper interpretation of in vivo imaging, is followed by a discussion of the fundamental principles of OCTA and the application of this advanced imaging modality to study and understand the choroid. The current limitations of OCTA and potential advancements that may improve the widespread adoption of this tool are also discussed. A detailed review of the OCTA features of the choroid in the healthy eye is followed by relevant findings in major chorioretinal diseases, including age-related macular degeneration, central serous chorioretinopathy, uveitis, and inherited retinal disorders.
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research

Related Links:

Conclusion: This study demonstrated that type 2 CNV was characterized by shorter duration of disease, smaller GVC, smaller GLD, and smaller flow area compared with type 1 CNV. Additionally, we showed that the duration of the disease correlated with GVC of the CNV.Ophthalmologica
Source: Ophthalmologica - Category: Opthalmology Source Type: research
Conclusions: The clinical characteristics of PEVAC in Korean patients were similar to those reported in patients of other ethnicities. Further studies are needed to better understand the nature of this newly described clinical entity. PMID: 31165650 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research
Anti –vascular endothelial growth factor (VEGF) therapy is currently the standard of care for patients presenting with neovascular age-related macular degeneration (nAMD). Polypoidal choroidal vasculopathy (PCV) is an important subtype of nAMD, and is an underrecognized diagnosis in many parts of the w orld. Correctly diagnosing PCV is crucial because the treatment for PCV may differ from the usual treatment for nAMD. The EVEREST II study, a multicenter prospective clinical trial from many countries in Asia, showed better vision results with photodynamic therapy combined with anti-VEGF injections than with anti-VEGF ...
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
Conclusion: OCTA analysis revealed different responses to anti-VEGF treatment depending on the location of neovascularization in neovascular AMD. Type 2 neovascularization was significantly regressed compared to type 1 neovascularization after anti-VEGF treatment. However, the changes in vascular density and visual outcome showed no significant differences between groups after 12 months of treatment. PMID: 31132283 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research
This article reviews technical aspects of OCT-A, its applications in chorioretinal disease, and known limitations of the technology. PMID: 31131663 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research
Publication date: Available online 7 May 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Lee-Jen Chen, Cheng-Kuo Cheng, Ling Yeung, Chang-Hao Yang, Shih-Jen Chen, Jiann-Torng Chen, Lee-Jen Chen, San-Ni Chen, Wen-Lu Chen, Cheng-Kuo Cheng, Sheng-Min Hsu, De-Kuang Hwang, Chi-Chun Lai, Chien-Hsiung Lai, Fenq-Lih Lee, Chang-Hao Yang, Chung-May Yang, Ling Yeung, Tsung-Tien Wu, Shih-Jen ChenPolypoidal choroidal vasculopathy (PCV) is a prevalent retinal disease predominantly occurs in Asians that shares some similarities seen in neovascular age-related macular degeneration. Recent large multicenter clinical trial...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Abstract Polypoidal choroidal vasculopathy (PCV) is a prevalent retinal disease predominantly occurs in Asians that shares some similarities seen in neovascular age-related macular degeneration. Recent large multicenter clinical trials on intravitreal anti-vascular endothelial growth factor (VEGF) agents and photodynamic therapy (PDT) have shed lights on the management of PCV. The Taiwan National Health Insurance had granted limited anti-VEGF agents and PDT for patients with PCV after the approval of required data submission, especially fundus angiography, optical coherence tomography, and visual acuity. In order ...
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
Optical coherence tomography angiography of types 1 and 2 choroidal neovascularization in age-related macular degeneration during anti-VEGF therapy: evaluation of a new quantitative method, Published online: 10 April 2019; doi:10.1038/s41433-019-0429-8Optical coherence tomography angiography of types 1 and 2 choroidal neovascularization in age-related macular degeneration during anti-VEGF therapy: evaluation of a new quantitative method
Source: Eye - Category: Opthalmology Authors: Source Type: research
CONCLUSION: The findings of this study indicate a possible ocular ABCC6 haploinsufficiency phenotype. Due to its late-onset and phenotypic similarities, misinterpretation as age-related macular degeneration is possible. PMID: 30923132 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Abstract Laser-induced choroidal neovascularization (CNV) model in nonhuman primates has played a critical role in the development of new therapies for neovascular age-related macular degeneration. The widespread use of this model, however, has been limited by its high costs, mainly due to the lower efficiency of animal use. To address this problem, we optimized the CNV model by repeated photocoagulation in the same eye of each animal and preliminarily evaluated this model for assessment of an anti-vascular endothelial growth factor (VEGF) agent. Seven rhesus monkeys were included and divided into two groups, whic...
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research
More News: Age-Related Macular Degeneration (AMD) | Angiography | Opthalmology | Study | Vitamin A