Mantle Cell Lymphoma Presenting as Colonic Lymphomatous Polyposis

A 60-year-old man presented with a 2-month duration of intermittent hematochezia and weight loss. There was no similar illness among family members. The physical examination was essentially normal. Laboratory tests showed essentially normal study with the exception of mild anemia and a high lactate dehydrogenase level  (765 U/L; normal range, 125–300 U/L). Colonoscopy showed multiple nodular lesions in the rectum (Figure A), sigmoid colon, and cecum. A computed tomography of the abdomen showed irregular, nonenhancing, mucosal thickening in the rectum, sigmoid colon (Figure B), and ileocecal region.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Electronic image of the month Source Type: research

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AbstractBackground.Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal lymphoma. Despite established clinical prognostic scoring such as that of the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Extranodal Lymphoma Study Group, outcome prediction needs to be improved. Several studies have indicated an association between changes in hematologic laboratory parameters with patient outcomes in PCNSL. We sought to assess the association between hematological parameters and overall survival (OS) in patients with PCNSL.Methods.Pretreatment blood tests were analyzed in patients wi...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Lymphoma, Neuro-Oncology Hematologic Malignancies Source Type: research
Conditions:   Acute Erythroid Leukemia;   Acute Lymphoblastic Leukemia;   Acute Megakaryoblastic Leukemia;   Acute Myeloid Leukemia;   Blasts Under 10 Percent of Bone Marrow Nucleated Cells;   Blasts Under 5 Percent of Bone Marrow Nucleated Cells;   Chronic Myelogenous Leukemia, BCR-ABL1 Pos itive;   Hematopoietic and Lymphoid Cell Neoplasm;   Human Immunodeficiency Virus Positive;   Myelodysplastic Syndrome;   Myelodysplastic Syndrome With Excess Bla...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
High-dose chemotherapy (HDT) followed by autologous hematopoietic stem cell transplantation (ASCT) is widely used in patients with malignant lymphomas. In Europe over 8,000 ASCTs for lymphoma were performed out of a total of 40,000 transplants according to the European Bone Marrow Transplant (EBMT) activity survey in 2017. ASCT is considered the standard treatment for eligible patients failing to achieve remission after first line chemotherapy or patients with relapsed or refractory lymphomas, including classical Hodkin's lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma, as well as con...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In 2014 a 66 year-old woman presented with anemia and an IgAk monoclonal spike. Bone marrow (BM) biopsy showed 80% lymphocytes and lymphoplasmacytoid cells. Computed Tomography (CT) scan documented neither adenopathy nor splenomegaly. Diagnosis of IgA lymphoplasmacytic lymphoma was made. After three lines of treatment, progressive disease with adenopathies, splenomegaly and ascites were documented on a CT scan. Our patient developed thrombocytopenia, transfusion-dependent anemia and clinical deterioration. We performed genetic studies of peripheral blood lymphoctyes with NGS approach. Given the identification ofMYD88 L265P...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
CONCLUSIONS: JWCAR029was effective and safe in treating refractory B-NHL. The composition of the tumor microenvironment has a potential impact inCAR T therapy response. PMID: 31444250 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Autoimmune cytopenias (AIC) such as immune thrombocytopenia or autoimmune hemolytic anemia are claimed to be essentially driven by a dysregulated immune system. Using next-generation immunosequencing we profiled 59 T and B cell repertoires (TRB and IGH) of 25 newly diagnosed patients with primary or secondary (lymphoma-associated) AIC to test the hypothesis if these patients present a disease-specific immunological signature that could reveal pathophysiological clues and eventually be exploited as blood-based biomarker. Global TRB and IGH repertoire metrics as well as VJ gene usage distribution showed uniform characteris...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion Crizotinib can be used for the treatment of advanced NSCLC with ALK fusion/translocation. It is highly effective and well tolerated. 
 DOI: 10.3779/j.issn.1009-3419.2019.08.02
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsPRES syndrome has an overall good prognosis and the evolution to epilepsy is rare. The severity and duration of PSH or seizure severity and EEG findings at PRES onset are not associated with worse neurological outcomes.
Source: Seizure - Category: Neurology Source Type: research
Conclusions: Rarely, an emergency splenectomy is required in complex settings, mostly refractory hematological conditions, in a deteriorating patient when all other measurements have failed. A multidisciplinary team approach is mandatory in the treatment of these complex cases.What is known• Conservative treatment is advised for splenic injury.• Many hematological disorders are responsible of splenic pathology.What is new• Emergency splenectomy in children for reasons other than trauma is a treatment of last resort that should be performed in a multidisciplinary context.• The outcome of emergency splene...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
ConclusionThe prevalence of PNH clones in MPN is similar to that described in MDS. Whether PNH clones influence MPN phenotype and complications should be studied prospectively in larger patient cohorts and over long term follow up.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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