Susceptible genes identified for childhood chronic kidney disease

(Kobe University) Childhood nephrotic syndrome is the most frequently occurring chronic kidney disease among children. A Japanese research team has identified a group of genes that are strongly related to the development of childhood nephrotic syndrome. The results of this study could shed light on the underlying mechanism for this disease. These findings were published on July 16 in the online edition of Journal of the American Society of Nephrology.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 6 September 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Giulio Kleiner, Emanuele Barca, Marcello Ziosi, Valentina Emmanuele, Yimeng Xu, Agustin Hidalgo-Gutierrez, Changhong Qiao, Saba Tadesse, Estela Area-Gomez, Luis C. Lopez, Catarina M. QuinziiAbstractNephrotic syndrome (NS), a frequent chronic kidney disease in children and young adults, is the most common phenotype associated with primary coenzyme Q10 (CoQ10) deficiency and is very responsive to CoQ10 supplementation, although the pathomechanism is not clear. Here, using a mouse model of CoQ ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
AbstractThe idiopathic nephrotic syndrome in childhood can be classified according to the International Study of Kidney Disease in Children (ISKDC) based on the response to steroids. Typically, steroid-sensitive nephrotic syndrome (SSNS) is characterised by minimal changes in disease (MCD) histology, whereas in steroid-resistant nephrotic syndrome (SRNS) focal segmental glomerulosclerosis (FSGS) is the most prevalent lesion. Patients with SSNS may develop frequent relapses and/or steroid dependency, which can be difficult to treat. New studies confirm the value of calcineurin inhibitors (CNIs) and mycophenolic acid in prev...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsEculizumab appears to be a potential treatment for patients with crescentic rapidly progressive C3 glomerulopathy. Its benefit in patients with non–rapidly progressing forms seems to be limited.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsThe congophilic properties of organized fibrillary deposits should not be solely relied on in differentiating fibrillary GN from renal amyloidosis. Mass spectrometry and DNAJB9 immunohistochemistry can be useful in making this distinction.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsWe showed safety and tolerability of a single-dose infusion of autologous MSCs in patients with CKD.
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionsEculizumab appears to be a potential treatment for patients with crescentic rapidly progressive C3 glomerulopathy. Its benefit in patients with non–rapidly progressing forms seems to be limited.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsThe congophilic properties of organized fibrillary deposits should not be solely relied on in differentiating fibrillary GN from renal amyloidosis. Mass spectrometry and DNAJB9 immunohistochemistry can be useful in making this distinction.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsWe showed safety and tolerability of a single-dose infusion of autologous MSCs in patients with CKD.
Source: Cytotherapy - Category: Cytology Source Type: research
Conclusions The congophilic properties of organized fibrillary deposits should not be solely relied on in differentiating fibrillary GN from renal amyloidosis. Mass spectrometry and DNAJB9 immunohistochemistry can be useful in making this distinction.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
cute; Abstract Chronic kidney disease (CKD) is associated with significant infectious complications leading to adverse health outcomes. This increased susceptibility to infection can be related to the nephropathy itself as observed in nephrotic syndrome, to the treatment especially in situations requiring immunosuppressive drugs or related to dialysis. Despite a less effective response to vaccination, some data emphasize similar benefits from immunization among people with CKD to the general population. However, some situations encountered in nephrology require adaptation of immunization practices. The aim of this...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
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