Susceptible genes identified for childhood chronic kidney disease

(Kobe University) Childhood nephrotic syndrome is the most frequently occurring chronic kidney disease among children. A Japanese research team has identified a group of genes that are strongly related to the development of childhood nephrotic syndrome. The results of this study could shed light on the underlying mechanism for this disease. These findings were published on July 16 in the online edition of Journal of the American Society of Nephrology.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionsEculizumab appears to be a potential treatment for patients with crescentic rapidly progressive C3 glomerulopathy. Its benefit in patients with non–rapidly progressing forms seems to be limited.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsThe congophilic properties of organized fibrillary deposits should not be solely relied on in differentiating fibrillary GN from renal amyloidosis. Mass spectrometry and DNAJB9 immunohistochemistry can be useful in making this distinction.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsWe showed safety and tolerability of a single-dose infusion of autologous MSCs in patients with CKD.
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionsEculizumab appears to be a potential treatment for patients with crescentic rapidly progressive C3 glomerulopathy. Its benefit in patients with non–rapidly progressing forms seems to be limited.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsThe congophilic properties of organized fibrillary deposits should not be solely relied on in differentiating fibrillary GN from renal amyloidosis. Mass spectrometry and DNAJB9 immunohistochemistry can be useful in making this distinction.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsWe showed safety and tolerability of a single-dose infusion of autologous MSCs in patients with CKD.
Source: Cytotherapy - Category: Cytology Source Type: research
Conclusions The congophilic properties of organized fibrillary deposits should not be solely relied on in differentiating fibrillary GN from renal amyloidosis. Mass spectrometry and DNAJB9 immunohistochemistry can be useful in making this distinction.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
cute; Abstract Chronic kidney disease (CKD) is associated with significant infectious complications leading to adverse health outcomes. This increased susceptibility to infection can be related to the nephropathy itself as observed in nephrotic syndrome, to the treatment especially in situations requiring immunosuppressive drugs or related to dialysis. Despite a less effective response to vaccination, some data emphasize similar benefits from immunization among people with CKD to the general population. However, some situations encountered in nephrology require adaptation of immunization practices. The aim of this...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
The objective of this follow-up study was to evaluate whether uCD80 elevation is actually associated with MCD and whether it signals better prognosis.MethodsWe evaluated uCD80 levels and a series of putative progression factors in a cohort of 64 patients with nephrotic syndrome (NS) seen between 2011 and 2016. We monitored progression of chronic kidney disease (CKD), assessed as a glomerular filtration rate of
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Background: Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving the function of podocyte epithelial cells, including podocyte foot process effacement.Summary: Developments in imaging technology are improving knowledge of the detailed structure of the human renal glomerulus and cortex. Podocyte foot processes attach themselves to the glomerular capillaries at the glomerular basement membrane (GBM) forming i...
Source: American Journal of Nephrology - Category: Neurology Source Type: research
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