People with complex regional pain syndrome getting raw deal

Symptoms not promptly recognised and multidisciplinary treatment often absent Related items fromOnMedica Does evidence support doctors recommending acupuncture for pain? Tai chi at least as beneficial as aerobic exercise for fibromyalgia Prescribing guidance helps GPs working in prisons Prescribe higher dose opioids for shorter time after surgery MHRA tightens licence restrictions on valproate for women
Source: OnMedica Latest News - Category: UK Health Source Type: news

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We examined the expression of TRPV1 in peripheral tissue and DRG neurons of CPIP model rats and we studied whether CPIP model could induce peripheral sensitization of TRPV1 channel and enhance DRG neuron excitability. Then we examined the therapeutic effects of locally applied TRPV1 specific antagonist AMG9810 on pain responses of CPIP model rats. Lastly, we explored the effects of AMG9810 on DRG neuron hyperexcitability and spinal glial activation induced by CPIP. Our results demonstrate that TRPV1 plays an important role in mediating the behavioral hypersensitivity of CPIP model rats via promoting peripheral nociceptor a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Amplified pain syndromes encompass a wide spectrum of musculoskeletal pain disorders that includes pediatric fibromyalgia, localized and diffuse amplified pain, and complex regional pain syndrome. Amplified pain can severely affect physical function, socialization, daily activities and quality of life in children and adolescents. This negative effect on quality of life can lead to prolonged disability and a profound effect on their behavioral and cognitive health. Because it is important that children experiencing this condition begin to use their body in a normal way, treatment and management is aimed at breaking the abno...
Source: Pain Management Nursing - Category: Nursing Authors: Source Type: research
Complex regional pain syndrome (CRPS) and fibromyalgia (FM) share many features. Both can cause severe pain and are considered to have a mechanism of action, including dysfunction of the sympathetic nervous system. However, they have clinical differences in pain range and degree. The present study aimed to find neurophysiologic differences between CRPS and FM using quantitative electroencephalography (QEEG). Thirty-eight patients with CRPS and 33 patients with FM were included in the analysis. Resting-state QEEG data were grouped into frontal, central, and posterior regions to analyze for regional differences. General line...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
This article reviews the case series reported from several countries describing patients with suspected severe side effects to the HPV vaccines. The described symptom clusters are remarkably similar and include disabling fatigue, headache, widespread pain, fainting, gastrointestinal dysmotility, limb weakness, memory impairment episodes of altered awareness, and abnormal movements. This constellation of symptoms and signs has been labeled with different diagnoses such as complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy (SFN), myalgic encephalomyelitis/chronic f...
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research
The objective of this study was to investigate the influence of visible physical signs on caregiver's patient-centered and empathetic behaviours in chronic pain context. Methods: A convenience sample of 21 nurses and 21 physicians participated in a descriptive study. PCC and empathy were evaluated from self-assessment and observer's assessment using a video of real patients with chronic pain. Results: The results show that caregivers have demonstrated an intraindividual variability: PCC and empathetic behaviours of the participants were significantly higher for patients who have visible signs of pain (rheumatoid ...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
European Journal of Pain,Volume 0, Issue ja, -Not available-.
Source: European Journal of Pain - Category: Anesthesiology Authors: Source Type: research
This article describes these syndromes and presents current treatment options.
Source: Nursing Clinics of North America - Category: Nursing Authors: Source Type: research
Complex regional pain syndrome (CRPS) develops after a range of injuries including fractures and soft tissue trauma to the extremities.43 The underlying mechanism of CRPS has not been fully elucidated and there are no specific medications approved for the treatment of CRPS. Oxidative stress results from an imbalance between ROS production and antioxidant defense systems. ROS have been implicated in many degenerative neurological conditions, such as Alzheimer's disease1 and Parkinson's disease18 and oxidative stress may also contribute to pain in various diseases, including fibromyalgia,26 diabetes,35,48 and CRPS.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research
CORR Insights®: Complex Regional Pain Syndrome After Distal Radius Fracture Is Uncommon and Is Often Associated With Fibromyalgia. Clin Orthop Relat Res. 2018 Apr;476(4):751-753 Authors: Moskal MJ PMID: 29538172 [PubMed - in process]
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research
Peripheral nerve injuries and diseases often lead to pain persisting beyond the resolution of damage, indicating an active disease-promoting process, which may result in chronic pain. This is regarded as a maladaptive mechanism resulting from neuroinflammation that originally serves to promote regeneration and healing. Knowledge on these physiological and pathophysiological processes has accumulated over the last few decades and has started to yield potential therapeutic targets. Key players are macrophages, T-lymphocytes, cytokines, and chemokines. In the spinal cord and brain, microglia and astrocytes are involved. Recen...
Source: Pain - Category: Anesthesiology Tags: NeuPSIG Reviews Source Type: research
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