Antifungal susceptibility of Aspergillus spp., Scedosporium spp. and Exophiala spp. isolated from patients with cystic fibrosis

Background: Moulds are frequently recovered from respiratory samples of cystic fibrosis (CF) patients. During the last decade, antifungal resistance in non-Candida species is increasingly reported. Azole resistance in Aspergillus fumigatus is a well-known problem and it was firstly reported in 1997 in three itraconazole-resistant clinical isolates. Since then, the main azole resistance mechanism reported are mutations at the CYP51A gene which encodes the azole drug target, the 14- α-sterol demethylase.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: UMP. 494 Source Type: research