Antifungal susceptibility of Aspergillus spp., Scedosporium spp. and Exophiala spp. isolated from patients with cystic fibrosis
Background: Moulds are frequently recovered from respiratory samples of cystic fibrosis (CF) patients. During the last decade, antifungal resistance in non-Candida species is increasingly reported. Azole resistance in Aspergillus fumigatus is a well-known problem and it was firstly reported in 1997 in three itraconazole-resistant clinical isolates. Since then, the main azole resistance mechanism reported are mutations at the CYP51A gene which encodes the azole drug target, the 14- α-sterol demethylase.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: T. Brito Devoto, S. Pola, J. Finquelievich, E. Rubeglio, S. Gamarra, G. Garc ía-Effron, M. Cuestas Tags: UMP. 494 Source Type: research
More News: Aspergillus | Candida | Cystic Fibrosis | Genetics | Infectious Diseases | Respiratory Medicine