Phototoxic effect of aluminium-chlorine and aluminium-hydroxide phthalocyanines on Leishmania amazonensis promastigotes forms in photodynamic therapy

Background: Leishmaniasis is a neglected infectious-parasitic disease caused by protozoa of the genus Leishmania. This disease is endemic in 98 countries with an estimate number of 350 million people in risk of infection. Approved drugs for the treatment of cutaneous leishmaniasis have numerous limitations, such as toxicity, long treatment period, therapeutic failure, serious adverse effects and even death. Thus, it is necessary to investigate new drugs and efficient alternative therapies that ensure less prolonged treatments with few adverse effects.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: UMP. 596 Source Type: research

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This study aimed to detect the Leishmania spp. in bats. 146 bats, representing 16 different species belonging to the Molossidae, Vespertilionidae, and Phyllostomidae families, were received and processed for collection of tissues. Skin samples were collected from 100% of the bats, and liver samples were collected from 87% (n=127). After evaluating the quality of the DNA extracted by means of PCR directed to the IRBP gene, the samples considered suitable for the Leishmania detection test were submitted for PCR directed to Leishmania kDNA, and to confirm positivity, were tested to the SSUrRNA gene-directed Nested-PCR. The Le...
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
CONCLUSIONS: Cutaneous parasitism in the healthy skin of humans with visceral leishmaniasis, although unusual, may be a source of infection for phlebotomine sandflies.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
This study aimed to characterize HVL in its epidemiological andtemporal aspects in Ceara State, from 2003 to 2017, as this is a neglected disease and a public health problem. This is an ecological study carried out with HVL confirmed cases in Ceara, using three blocks of years (2003 to 2007, 2008 to 2012 and 2013 to 2017). The disease presented an endemic behavior, affecting mainly male residents in the urban area, especially children under five and young adults between 30 and 49 years old. HVL is recorded in all the municipalities, for more than 10 years, with a growing trend and territorial expansion to the Central and E...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
by Mar ília Fonseca Rocha, Érika Monteiro Michalsky, Fabiana de Oliveira Lara-Silva, Josiane Lopes Valadão, João Carlos França-Silva, Letícia Cavalari Pinheiro, Joel Fontes de Sousa, Ronaldo Cardoso dos Santos, Marcelo Dias Soares, Consuelo Latorre Fortes-Dias, Edelberto Santos Dias Visceral leishmaniasis (VL) is a neglected tropical disease, caused byLeishmania (Kinetoplastida, Trypanosomatidae) species. In Brazil, the transmission of this parasite essentially occurs through the bite ofLutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae) previously infected withLeishmania ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Evaluation of canine leishmaniosis vaccine CaniLeish® under field conditions in native dog populations from an endemic Mediterranean area - a randomized controlled trial. Acta Trop. 2020 Feb 05;:105387 Authors: Velez R, Domenech E, Rodríguez-Cortés A, Barrios D, Tebar S, Fernández-Arévalo A, Aguilar R, Dobaño C, Alberola J, Cairó J, Gállego M Abstract Dog vaccination is considered an effective way of reducing Leishmania infantum infection incidence in the canine population, as well as its transmission to humans. However, the use of partially effecti...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Abstract Despite being considered a tropical disease, visceral leishmaniasis (VL) caused by L. infantum is also endemic in the Mediterranean Europe and represents an increasing cause of morbidity and mortality in solid organ transplant (SOT) recipients. VL occurring in kidney transplant recipients is a severe event, often worsening the renal damage and leading to poor outcome. It is believed that most of VL cases in transplant recipients are caused by reactivation of a pre-existent, dormant leishmanial infection induced by the immunosuppressive drugs. Nevertheless, the prevalence of asymptomatic Leishmania infecti...
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
CONCLUSIONS: Extracts of A. mucosa are promising sources of novel antileishmanial compounds.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Leishmanicidal activity of Piper marginatum Jacq. from Santarém-PA against Leishmania amazonensis. Exp Parasitol. 2020 Jan 28;:107847 Authors: Macedo CG, Fonseca MY, Caldeira AD, Pinto de Castro S, Lima WP, Gonçalves Borsodi MP, Sartoratto A, Nascimento da Silva M, Salgado CG, Bergmann BR, Ferreira Castro KC Abstract Leishmaniasis is an infectious disease that has high endemicity and is among the six parasitic diseases of higher occurrence in the world. The current treatments are limited due to their toxicity, treatment resistance and high cost which have increased the search for new sub...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
The genus Tanacetum includes some popular endemic species of the flora of Iran, with important medicinal properties. In a project directed at structurally interesting bioactive metabolites from Iranian endemic species, we studied Tanacetum sonbolii Mozaff. Eight compounds comprising six phenolic and two terpenoidal compounds were isolated from the ethyl acetate extract of the aerial parts of the plant by normal and reverse phase chromatography. Their structures were established mainly by 1D and 2D NMR spectroscopic techniques, including 1H-1H COSY, HSQC and HMBC methods and confirmed by comparing their NMR data with those ...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
AbstractWith sand flies as the main vectors,Leishmania species cause ancient zoonotic diseases called leishmaniasis. Iran is an endemic country regarding cutaneous leishmaniasis. A number of 100 smear slides were collected from cutaneous lesions referred to Ahvaz health centers. The DNA was extracted and ITS1 –PCR using LITSR and L5.8S primer pair was performed to detect the genusLeishmania. Then, enzymatic digestion of PCR products was done byHaeIII (species detection),TaqI (strain detection),DpnI andHpaII (mutation assessment). Furthermore, 50 samples were sent for sequencing. Microscopic examination showed amastig...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
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