Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents

Publication date: Available online 27 July 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mei Lu, Qiujun Qiu, Xiang Luo, Xinrong Liu, Jing Sun, Cunyang Wang, Xiangyun Lin, Yihui Deng, Yanzhi SongAbstractAlthough active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly” phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.Graphical Abstract
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research