CPR: A neglected but important part of fighting the opioid crisis

Opioid overdose is a frightening and potentially life-threatening event. Rescue drugs like naloxone are lifesaving, but the value of CPR doesn’t get as much attention. And it should. How does opioid overdose lead to death? Opioids (like oxycodone, heroin, and fentanyl) bind to special receptors in the brain called mu receptors. These receptors are responsible for a variety of functions, most importantly breathing. When the mu receptor is stimulated by an opioid, it releases chemicals that work downstream on parts of the brain that tell the body to slow down breathing, or even stop it altogether. This respiratory depression or apnea, when breathing stops, is the primary cause of death in opioid overdose. Reversing the effects of opioid overdose Thankfully, there is an antidote that can help to reverse the effects of opioids and save lives. As highlighted by Dr. Scott Weiner in his post in May 2018, naloxone can be used to reverse the effects of opioids and help to restore breathing. As we learned, it does this by displacing the opioid from the mu receptor, which reestablishes the signal to breathe. Naloxone can be given by a variety of routes, including by nasal spray or by an injection. It is easy to use, works quickly, and has saved a lot of lives after an opioid overdose. But it can take several minutes for naloxone to work. On average, when delivered nasally it takes around two to five minutes for naloxone to take effect. In someone who isn’t breathing, those m...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction First Aid Health Source Type: blogs

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miR‑205 suppresses cell migration, invasion and EMT of colon cancer by targeting mouse double minute 4. Mol Med Rep. 2020 May 18;: Authors: Fan Y, Wang K Abstract Colon cancer is one of the most frequent malignant tumors, and microRNA (miR)‑205 is involved in the tumor progression. The present study aimed to explore the effects of miR‑205 on human colon cancer and its targeting mechanism. The levels of miR‑205 and mouse double minute 4 (MDM4) were determined via reverse transcription‑quantitative (RT‑q)PCR and western blot analysis. A luciferase activity assay was performed t...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Conclusions: 60% of patients with MDD and/or AAD had at least one additional NCCD, which significantly increased the economic and humanistic burden. These findings are important for payers and clinicians in making treatment decisions. These results underscore the need for development of multi-pronged interventions which aim to improve quality of life and reduce activity limitations among patients with mental health disorders and NCCDs. PMID: 32468879 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
CONCLUSION: The literature in the area of addiction is growing rapidly; however, the results are still mixed. Given the complexity of the problem, the goal should be the discovery of a minimal invasive and inexpensive diagnostic procedure to identify a prognostic and therapeutic target. The correlation of the expression of biomarkers on buccal cells could be valuable for the design of predictive and therapeutic strategies. PMID: 32468470 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSIONS: Results shed more light toward the possible use of VR for distant self-administered evaluation of the frail status. PMID: 32468314 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Giannoulis K, Giannouli V Abstract The goal of this study is to examine subjective quality of life-life satisfaction, religiousness, and spiritual experience in healthy younger and older adults, as well as in older patients suffering from severe cardiovascular disease, while examining the role of marital status, employment and socioeconomic status, existence of social network, urbanicity, education, depression, and personal opinion about the country's current socioeconomic situation. Results revealed that there are no age differences and that the role of demographic variables as predictors of religiousness...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSION: T2DM patients have cognitive deficits on several domains compared to healthy participants. Domain specific neuropsychological deficits in middle aged T2DM patients have a significant impact on HRQOL. PMID: 32468306 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Kaimara P, Plerou A, Deliyannis I Abstract Electroencephalography (EEG) systems and brain-computer interfaces (BCIs) are terms frequently involved in the field of neurological research. Under a technological point of view, BCI is considered to be a significant achievement within the frame of learning disabilities rehabilitation. Nevertheless, the specifications for efficient use for cognitive enhancement and its potential boundaries are under concern. Author's main objective is to discuss BCI concrete components and potential advances as well as depict potential limitations while using technological device...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Vlamou E, Papadopoulos B, Plerou A Abstract Fuzzy logic is an innovative scientific field with several successful applications. Genetic algorithms and fuzzy logic systems fusion provide real-world problems modeling through the development of intelligent and adaptive systems. Moreover, the statistical analysis of the epidemiology of infectious diseases, which combines fuzzy logic aspects, is vital for perceiving their evolution and control potential. Author's objective is initially to provide a review of the efficiency of fuzzy logic applications. The advanced implementation of fuzzy logic theory in epidemi...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Some people on the streets of New York City recently appeared to be overdosing on opioid painkillers after their breathing slowed and they became lethargic. Others appeared to be overdosing on crack cocaine, exhibiting agitated and violent behavior. Experts at the National Institute on Drug Abuse (NIDA), however, say those zombielike streetwalkers were on the same drug: K2, or synthetic marijuana. In all, the NIDA reported that 130 New Yorkers were hospitalized after smoking the drug that can be purchased over-the-counter at less-than-reputable bodegas. The next day, NYPD officers inspected five retail establishments o...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
By JOSEPH KRAININ, M.D. His voice had the unusual ability to convey both aggressive muscularity and profound vulnerability. Scott Weiland and Stone Temple Pilots were icons of my adolescence. Personally, my memory of Mr. Weiland will always be inextricably linked with “Plush,” that initial hit single which, upon first listen, instantly captivated me and thousands of other kids like me. During my high school days, “Plush” was elevated to the highest sonic status possible, joining Metallica’s “Enter Sandman” and Pearl Jam’s” Black” as an essential component of our f...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: THCB Pain Scott Weiland Stone Template Pilots Source Type: blogs
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