Metabolite profiling of “green” extracts of Corylus avellana leaves by 1H NMR spectroscopy and multivariate statistical analysis

Publication date: Available online 26 July 2018Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Antonietta Cerulli, Milena Masullo, Paola Montoro, Jan Hošek, Cosimo Pizza, Sonia PiacenteAbstractCorylus avellana L. (Betulaceae) leaves, consumed as infusion, are used in traditional medicine, for the treatment of hemorrhoids, varicose veins, phlebitis, and edema due to their astringent, vasoprotective, and antiedema properties. In previous works we reported from the leaves of Corylus avellana cv. “Tonda di Giffoni” diarylheptanoid derivatives, a class of plant secondary metabolites with a wide variety of bioactivities. With the aim to give an interesting and economically feasible opportunity to C. avellana leaves as source of functional ingredients for pharmaceutical and cosmetic formulations, “green” extracts were prepared by employing “eco-friendly” extraction protocols as maceration, infusion and SLDE-Naviglio extraction. Metabolite profiles of the extracts were obtained by 1H NMR experiments and data were processed by multivariate statistical analysis to highlight differences in the extracts and to evidence the extracts with the highest concentrations of bioactive metabolites. Based on the NMR data, a total of 31 compounds were identified. The metabolite variation among the extracts was evaluated using Principle Component Analysis (PCA) and Partial Least Squares-Discriminant Analysis (PLS-DA). Furthermore, the tot...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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​The figure-of-eight suture is a fascinating technique, often used in unique cases. The stitch is extremely secure and easy to place. It can be used to save time during long, complicated repairs and to create additional strength in high-tension areas. The figure-of-eight stitch can be modified to bring skin edges together or close off small bleeding arteries, varicose veins, or even bleeding hemorrhoids. Multiple figure-of-eight sutures can be used in a row.The idea is to use a single suture to surround a small area of tissue in a box shape to close a laceration or put pressure on a small site. Figure-of-eight sutures ca...
Source: The Procedural Pause - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Publication date: Available online 29 May 2019Source: Plant Physiology and BiochemistryAuthor(s): Abbas Khojasteh, Raul Sanchez-Muñoz, Elisabeth Moyano, Mercedes Bonfill, Rosa M. Cusido, Regine Eibl, Javier PalazonAbstractRuscus aculeatus is a threatened medicinal plant whose main bioactive components, the ruscogenins, have long been used in the treatment of hemorrhoids and varicose veins, but recently demonstrated activity against some types of cancer. Plant cell biofactories could constitute an alternative to the whole plant as a source of ruscogenins. In this pipeline, despite the in vitro recalcitrance of R. acu...
Source: Plant Physiology and Biochemistry - Category: Biochemistry Source Type: research
Authors: Yetkin E, Ozturk S Abstract Atherosclerotic disease of the vessels is a significant problem affecting mortality and morbidity all over the world. However, dilatation of the vessels either in the arterial system or in the venous territory is another vessel disease. Varicocele, pelvic, and peripheral varicose veins and hemorrhoids are aneurysms of the venous vascular regions and have been defined as dilating venous disease, recently. Coronary artery ectasia, intracranial aneurysm, and abdominal aortic aneurysm are examples of arterial dilating vascular diseases. Mostly, they have been defined as variants of ...
Source: International Journal of Vascular Medicine - Category: Cardiology Tags: Int J Vasc Med Source Type: research
This study will provide a basis for evaluating future changes in practice.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
CONCLUSION: Numerous successful administrations of this drug in a variety of clinical conditions lead to promising perspectives toward it. Sclerotherapy with polidocanol as a minimal-invasive method (having similar outcomes like the prevalent surgeries) may reduce the rate of complications. Furthermore, for determining the most appropriate method and dosage, randomized clinical trials are needed, confirming and providing more clear instructions for different conditions. PMID: 29473522 [PubMed - as supplied by publisher]
Source: Current Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Clin Pharmacol Source Type: research
When you’re pregnant the last thing you are thinking about is working out. However pre-natal exercise not only helps reduce the amount of weight you gain during pregnancy but helps alleviate some of the symptoms you suffer during it. And let’s face it, if you’re in your first trimester you may be willing to do just about anything to feel better! In general, we know that exercising gives you more energy. When you’re pregnant you may be feeling more tired than usual and even a little moody. Working out will help give you that extra energy and will also help with any mood swings and trouble sleeping. E...
Source: Cord Blood News - Category: Perinatology & Neonatology Authors: Tags: pregnancy Source Type: blogs
This study shows that new chronic opioid use after surgery may be one of the most common complications after surgery,” said lead study author Dr. Chad Brummett of the University of Michigan in Ann Arbor. “Given that the rates of new chronic use did not differ between major and minor surgery, this suggests that patients continue to use their opioids for reasons other than the pain from the surgery,” Brummett added by email. Addressing patients’ acute pain during their recovery from surgery may be a way to prevent them from becoming a statistic in the opioid epidemic, he suggested. About 50 million pe...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, Itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis, and hemorrhoids. Polidocanol eligibility as an alternative prescription, in comparison to other standard medications in each condition, is also discussed meticulously afterwards in this paper.
Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access Poster Source Type: research
This study will provide a basis for evaluating future changes in practice.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Planta Med DOI: 10.1055/s-0042-119728The genus Ruscus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs. Among the approximately seven species spread throughout Europe up to Iran, Ruscus aculeatus L. (butcherʼs broom) is the most widely distributed and appreciated. This review provides an overview of the traditional use of Ruscus spp., the current knowledge of the chemistry of this genus, and the pharmacological studies carried out on Ruscus spp. extracts. The underground parts of Ruscus plants are a source of steroidal sapo...
Source: Planta Medica - Category: Drugs & Pharmacology Authors: Tags: Reviews Source Type: research
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